Un nuevo preparado de levodopa benserazida en parkinsonianos con fluctuaciones motoras refractarias a tratamientos con L-dopa standard. / [A new levodopa benserazide preparation for Parkinsons disease with motor fluctuations refractory to standard L-dopa]
Medicina (B.Aires)
; 51(6): 561-7, 1991.
Article
em Es
| BINACIS
| ID: bin-38108
Biblioteca responsável:
AR2.1
ABSTRACT
As Parkinsons disease worsens, many patients develop motor fluctuations which usually correlate directly or indirectly with L-dopa plasma levels. A new L-dopa-benserazide HBS preparation (Madopar) a control release pharmaceutical formulation which is activated when it contacts gastric fluid thus providing more stable L-dopa plasma levels, was assayed. Ten patients with a diagnosis of idiopathic Parkinsons disease and motor fluctuations otherwise unresponsive to conventional therapy were selected. The average age was 62 years and the duration of the disease 9 years. The motor status was evaluated on an hourly basis with the Kings College Parkinsons disease rating scale; in addition, a nocturnal disability scale (Lees) was used. Out of the 10 patients, 2 dropped out within the first month due to worsening of parkinsonian signs, while 7 of the remainders preferred HBS preparation to the previous treatment. The number of off hours in this group was reduced by 58
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Coleções:
01-internacional
/
06-national
/
AR
Base de dados:
BINACIS
/
LILACS
Assunto principal:
Benserazida
/
Levodopa
/
Transtornos dos Movimentos
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Medicina (B.Aires)
Assunto da revista:
MEDICINA
Ano de publicação:
1991
Tipo de documento:
Article
País de publicação:
Argentina