Perinatal undernutrition impairs spatial learning in recovered adult rats.

Córdoba, N E; Arolfo, M P; Brioni, J D; Orsingher, O A

Córdoba, N E; Arolfo, M P; Brioni, J D; Orsingher, O A.

Afiliação

Orsingher, O A; Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina..

Acta Physiol. Pharmacol. Ther Latinoam ; 44(3): 70-6, 1994.

Article em En | BINACIS | ID: bin-37362

Biblioteca responsável: AR1.1

ABSTRACT

ABSTRACT

Learning ability of adult rats undernourished at perinatal age and nutritionally recovered (D-rats) was assayed in the Morris water maze test as compared with controls (C-rats). D-rats showed longer escape latencies to locate a hidden platform in absence of proximal cues during the acquisition period. Swimming pre-training experience did not improve this shortcoming. Retention scores obtained 1, 3, 10 and 30 days after training showed that spatial information was efficiently consolidated after acquisition since D-rats performed as well as C-rats on retention tests. A cue learning task revealed no significant differences between both groups. These results suggest that perinatal undernutrition induces, even after a long period of nutritional recovery, a deficit in efficient place navigation in adult rats.

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Coleções: 06-national / AR Base de dados: BINACIS Idioma: En Revista: Acta Physiol. Pharmacol. Ther Latinoam Ano de publicação: 1994 Tipo de documento: Article País de publicação: Argentina

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