Correlación entre la proliferación celular y la expresión de receptores beta adrenérgicos en linfocitos T activados. / [Relation between cell proliferation and beta adrenergic receptor expression in activated T lymphocytes]
Acta Physiol. Pharmacol. Ther Latinoam
; 45(1): 43-8, 1995.
Article
em Es
| BINACIS
| ID: bin-37195
Biblioteca responsável:
AR1.1
ABSTRACT
beta adrenergic receptors (R) on murine lymphocytes stimulated with concanavalin A (Con A) and tumor lymphoid cell line (BW5147) were characterized by beta radioligand binding of 125Icyanopindolol (125I-CYP). The functionality was also assesses by hormone-dependent changes in cyclic 3, 5, adenosine monophosphate (cAMP) levels on intact cell. Both types of cells displayed a reduced number of beta adrenergic receptors by 125I-CYP specific binding. However BW5147 cell line were unable to respond to beta agonist stimulation meanwhile the response of lymphocytes stimulated with Con A was lower than normal lymphocytes. Despite this difference both kind of cells displayed an increase in cAMP production induced by Prostaglandin E1 (PGE1). It can be concluded that functional beta R are absent in BW5147 cell line. The possible implication of alternative transmission pathway and neuroendocrine control in tumor lymphoid cells is discussed.
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Idioma:
Es
Revista:
Acta Physiol. Pharmacol. Ther Latinoam
Ano de publicação:
1995
Tipo de documento:
Article
País de publicação:
Argentina