Experimental autoimmune myocarditis: a suitable model to study neuroimmune crosstalk
Acta physiol. pharmacol. ther. latinoam
; 45(4): 201-12, 1995. ilus, tab
Article
em En
| BINACIS
| ID: bin-23105
Biblioteca responsável:
BR1.1
ABSTRACT
This review regards the main functional characteristics of hearts subjected to an autoimmune response focusinf especially on the role of T lymphocytes and autoantibodies in the development of cardiac dysfunction. Evidence of a strong association in the onset and time-course of immune response and cardiac dysfunction is presented and the results are viewed comparatively with myocarditis models induced by heart, parasite or virus inoculation. Cardiac damage is evaluated regarding various aspects, namely histologic, immunologic, biochemical, pharmacologic, physiologic. Finally, the model, for its characteristics of resulting from an autoimmune response against the heart with functional consequences, has proved its usefulness to study neuroimmune interaction, mainly the immune to nervous direction, as autoantibodies and T cell-derived factors have a role in cardiac failure. (AU)
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Doenças Autoimunes
/
Miocardite
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta physiol. pharmacol. ther. latinoam
Ano de publicação:
1995
Tipo de documento:
Article
/
Project document