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Variable number tandem repeats in the promoter region of prostacyclin synthase gene in choline deficient rats
Denninghoff, Valeria C; Ossani, Georgina P; Uceda, Ana M; Avagnina, Maria A; Elsner, Boris; Monserrat, Alberto J.
Afiliação
  • Denninghoff, Valeria C; University of Buenos Aires (CONICET). Faculty of Medicine. Department of Pathology. Centre of Experimental Pathology. Buenos Aires. Argentina
  • Ossani, Georgina P; University of Buenos Aires (CONICET). Faculty of Medicine. Department of Pathology. Centre of Experimental Pathology. Buenos Aires. Argentina
  • Uceda, Ana M; University of Buenos Aires (CONICET). Faculty of Medicine. Department of Pathology. Centre of Experimental Pathology. Buenos Aires. Argentina
  • Avagnina, Maria A; Centre for Medical Education and Clinical Investigation. Department of Pathology. Buenos Aires. Argentina
  • Elsner, Boris; Centre for Medical Education and Clinical Investigation. Department of Pathology. Buenos Aires. Argentina
  • Monserrat, Alberto J; University of Buenos Aires (CONICET). Faculty of Medicine. Centre of Experimental Pathology. Buenos Aires. Argentina
Biocell ; Biocell;34(2): 65-70, Aug. 2010. tab
Article em En | BINACIS | ID: bin-127238
Biblioteca responsável: AR40.1
ABSTRACT
Weanling Sprague-Dawley rats were fed on a choline-deficient diet with hydrogenated vegetable oil and corn oil as lipids develop acute renal failure. Pathogenesis of the latter is controversial and an ischemic mechanism has been proposed. Arachidonic acid derivatives are involved in the regulation of vascular tonus. Vasospasm could be due to an increase in tromboxane A2-mediated vasoconstriction or to a decrease in prostacyclin-induced vasodilatation. Enzymes involved in the synthesis of both compounds are tromboxane A2- and prostacyclin-synthase respectively. The aim of this study was to identify the variable number tandem repeats (VNTR) in the promoter region of prostacyclin synthase gene and verify if there exists a relationship between the occurrence of VNTR in those choline-deficient rats which die because of acute renal failure and those which do not. We verified the presence of the VNTR in the prostacyclin synthase rat gene, but we did not find any difference in the molecular weight of the alleles between experimental and control rats. Renal reparation of the acute kidney injury due to choline deficiency in some rats is not related with differences in VNTR in the promoter region of the prostacyclin synthase gene.(AU)
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Texto completo: 1 Coleções: 06-national / AR Base de dados: BINACIS Assunto principal: Deficiência de Colina / Oxirredutases Intramoleculares / Sistema Enzimático do Citocromo P-450 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Biocell Ano de publicação: 2010 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 06-national / AR Base de dados: BINACIS Assunto principal: Deficiência de Colina / Oxirredutases Intramoleculares / Sistema Enzimático do Citocromo P-450 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Biocell Ano de publicação: 2010 Tipo de documento: Article