Interacción entre proteínas y glicanos en la regulación fisiológica de las células T / How do protein-glycan interactions regulate T-cell physiology?
Medicina (B.Aires)
; Medicina (B.Aires);66(4): 357-362, 2006.
Article
em Es
| BINACIS
| ID: bin-123215
Biblioteca responsável:
BR1.1
ABSTRACT
Recent evidence indicates that protein-glycan interactions play a critical role in different events associated with the physiology of T-cell responses including thymocyte maturation, T-cell activation, lymphocyte migration and T-cell apoptosis. Glycans decorating T-cell surface glycoproteins can modulate T-cell physiology by specifically interacting with endogenous lectins including selectins and galectins. These endogenous lectins are capable of recognizing sugar structures localized on T-cell surface glycoproteins and trigger different signal transduction pathways leading to differentiation, proliferation, cell cycle regulation or apoptosis. Protein-carbohydrate interactions may be controlled at different levels, including regulated expression of lectins during T-cell maturation and differentiation and the spatio-temporal regulation of glycosyltransferases and glycosidases, which create and modify sugar structures present in T-cell surface glycoproteins. This article briefly reviews the mechanisms by which protein-carbohydrate interactions modulate immunological processes such as T-cell activation, migration and apoptosis.(AU)
Texto completo:
1
Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Polissacarídeos
/
Linfócitos T
/
Proteínas
Limite:
Humans
Idioma:
Es
Revista:
Medicina (B.Aires)
Ano de publicação:
2006
Tipo de documento:
Article
/
Project document
País de publicação:
Argentina