Erythrophagocytosis assay in patients with autoimmune hemolytic anemia
Medicina [B.Aires]
; 61(1): 49-52, 2001. tab, gra
Article
em En
| BINACIS
| ID: bin-10517
Biblioteca responsável:
BR1.1
ABSTRACT
The aim of this paper is to evaluate the erythrophagocytosis assay (EA) in patients with autoimmune hemolytic anemia (AIHA). Direct antiglobulin test (DAT), indirect antiglobulin test (ITA) and EA were performed in blood samples from 46 patients with presumed AIHA. The EA was carried out incubating patientserythocytes and peripheral blood monocyte. A total of 200 monocytes were analysed to determine the percentage of active phagocytic cells (porcentage APC). In 9 of these patients the applied treatment was evaluated by DAT,IAT and EA. In 14 transfusion requirements, the compatibility tets and EA were performed. For EA, patientsmonocyte were incubated with erytrocytes from previously selected units sensitized with patientssera. The porcentage of APC was 32.1 +/- 1.7 in 35 patients with positive DAT and 17.8 +/- 1.3 in 11 patients with negative DAT. This last value was significantly higher than that with negative controls (3.7 +/- 0.3) (p= 0.01). As regards the applied treatment, patients with a successful response (n=6) showed a significant decrease in the initial porcentage APC (31.8 +/- 1.6 to 15.3 +/- 2.4; p= 0.05) while DAT and IAT remained positive. In those patients who required blood transfusion the compatibility test were positive with all the units to be transfused, whereas the porcentage APC varied for each one. Blood units were selected according to the lower porcentage APC. (AU)
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Fagocitose
/
Eritrócitos
/
Anemia Hemolítica Autoimune
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Medicina [B.Aires]
Ano de publicação:
2001
Tipo de documento:
Article