Structural Assessment of Chemical Constituent of Sidaguri (Sida rhombifolia Linn) and Its Ability to Inhibit Cyclooxygenase
Pesqui. bras. odontopediatria clín. integr
; 19(1): 4773, 01 Fevereiro 2019. tab, graf
Article
em En
| LILACS, BBO
| ID: biblio-998267
Biblioteca responsável:
BR1264.1
ABSTRACT
Objective:
To elicit the structure of isolated compounds from roots of sidaguri (Sida rhombifolia Linn). Material andMethods:
Several organic standard protocols were involved, including extraction, fractionation, and phytochemical testing. Further spectroscopy methods, FTIR and 1HNMR, were used to determine the predicted structure of molecules, while their ability to inhibit cyclooxygenase (COX 1 and 2) were tested using in vitro method.Results:
Overall assessments showed that the structure of the sidaguri is a long chain aliphatic carboxylic acid and identified as Z-3, 6, 6 trimethylhept-2-en-1-ol (T12) and nonanoic (T13). Both isolates significantly inhibit COX-1 and COX-2 non-selectively (the COX-1/COX-2 ratio for T12 was 0.91 and 0.82; while COX-1/COX-2 ratio for T13 was 0.89 and 0.87 at concentrations of 0.05 and 0.025 µg/mL respectively).Conclusion:
The active compounds of Sidaguri have antiinflammatory effect by inhibiting COX non-selectively.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
BBO
/
LILACS
Assunto principal:
Análise Espectral
/
Ciclo-Oxigenase 1
/
Ciclo-Oxigenase 2
/
Anti-Inflamatórios
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pesqui. bras. odontopediatria clín. integr
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de publicação:
Brasil