Evaluation of vitamin D plasma levels after mild exposure to the sun with photoprotection
An. bras. dermatol
; An. bras. dermatol;94(1): 56-61, Jan.-Feb. 2019. tab, graf
Article
em En
| LILACS
| ID: biblio-983734
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
Most of the organism's vitamin D (VD) is obtained through the cutaneous synthesis after exposure to the sun's UVB radiation. Sunscreens are indicated for the prevention of actinic damage to the skin, however, there are few clinical trials assessing the synthesis of cutaneous VD in real-life situations of sun exposure with ordinary clothing and usual photoprotection.Objectives:
To evaluate the synthesis of VD with suberythemal sun exposure in healthy adults using topical photoprotection (SPF 30).Methods:
Quasi-experimental study, conducted at Rio de Janeiro (Brazil), during winter, with 95 healthy adults who had 25-OH-VD checked twice, 24 hours apart, and were exposed to the sun (UVB=20 mJ/cm2), according to a randomized grouping SC - use of SPF 30 on the face, neck and chest (n=64), NO - no sunscreens (n=10), CO - confined from sun exposure for 24h (n=21). The groups were matched according to the propensity score related to gender, age, phototype, body mass index, glycosylated hemoglobin and baseline levels of VD. The outcome evaluated was the variation (ΔVD) in serum level of 25-OH-VD (ng/ml) between the groups.Results:
A statistically significant difference was identified between CO and SC groups [median (p25-p75)] ΔVD =1.4 (-0.3-3.6) vs. 5.5 (4.8-6.6); p<0.01. There was no difference between SC and NO groups 5.4 (3.1-6.1) vs. 4.1 (2.5-6.0); p=0.17. Studylimitations:
Laboratory analysis technique (chemiluminescence) with great variability, loss of food intake standardatization, unbalanced groups.Conclusions:
Suberythemal sun exposure with sunscreen (SPF 30) provides similar vitamin D serum variation than without photoprotection in healthy adults.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Luz Solar
/
Protetores Solares
/
Vitamina D
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil