Bacteremia and meningitis caused by OXA-23-producing Acinetobacter baumannii - molecular characterization and susceptibility testing for alternative antibiotics
Braz. j. microbiol
; Braz. j. microbiol;49(supl.1): 199-204, 2018. tab, graf
Article
em En
| SES-SP, SESSP-IIERPROD, SES-SP
| ID: biblio-974325
Biblioteca responsável:
BR31.1
Localização: BR31.1; 2018_P-020
ABSTRACT
Abstract Background:
Carbapenem-resistant Acinetobacter baumannii infection is a concern in developing countries due to high incidence, few therapeutic options, and increasing costs.Objective:
Characterize and analyze the antibiotic susceptibility patterns of carbapenem-resistant A. baumannii isolates and evaluate clinical data of meningitis and bacteremia caused by this microorganism.Methods:
Twenty-six A. baumannii isolates from 23 patients were identified by MALDI-TOF and automated methods and genotyped using pulsed field genotyping electrophoresis. Clinical data and outcomes were evaluated. Susceptibility of isolates to colistin, tigecycline, meropenem, imipenem, and doxycycline was determined.Results:
Mortality due to A. baumannii infections was 73.91%; all patients with meningitis and 7/8 patients with ventilator-associated pneumonia died. All isolates were susceptibility to polymyxin (100%; MIC50, MIC90 1 µg/mL, 1 µg/mL) and colistin (100%; MIC50, MIC90 2 µg/mL, 2 µg/mL), and 92% were susceptible to tigecycline (MIC50, MIC90 1 µg/mL, 1 µg/mL) and doxycycline (MIC50, MIC90 2 µg/mL, 2 µg/mL). bla OXA-23 was identified in 24 isolates. Molecular typing showed 8 different patterns 13 isolates belonged to pattern A (50%).Conclusion:
Carbapenem-resistant A. baumannii infections mortality is high. Alternative antimicrobial therapy (doxycycline) for selected patients with carbapenem-resistant A. baumannii infection should be considered.Palavras-chave
Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IIERPROD
Assunto principal:
Bacteriemia
/
Acinetobacter baumannii
/
Meningite
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Braz. j. microbiol
Ano de publicação:
2018
Tipo de documento:
Article