Estimulación cerebral profunda en enfermedad de Parkinson / Deep brain stimulation in Parkinson's disease
Rev. méd. Chile
; 146(5): 562-569, mayo 2018. tab, graf
Article
em Es
| LILACS
| ID: biblio-961432
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Deep brain stimulation is an essential therapeutic tool in Parkinson's disease.Aim:
To assess the results of a series of patients with Parkinson's disease treated with micro-electrode guided subthalamic nucleus stimulation. Material andMethods:
Twenty patients with idiopathic Parkinson's disease were studied (10 males). Three months after surgery, we analyzed the change in motor disturbances, medication need to control symptoms and quality of life.Results:
We observed a significant improvement in all the assessed variables. Motor involvement determined as OFF hours and expressed as percentage of the day changed from 30 ± 15 to 10 ± 7% in the preoperative and postoperative periods, respectively. ON hours without dyskinesia changed from 17 ± 16 to 78 ± 21%. ON hours with dyskinesia changed from 53 ± 23 to 12 ± 15%. Medication need changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson's Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During the 5-year follow-up a continuous improvement of symptoms was observed.Conclusions:
Micro-electrode guided subthalamic nucleus functional surgery in patients with Parkinson's disease has good immediate and late results.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Doença de Parkinson
/
Núcleo Subtalâmico
/
Estimulação Encefálica Profunda
Tipo de estudo:
Observational_studies
/
Qualitative_research
Aspecto:
Patient_preference
Limite:
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Chile