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Analysis of laser therapy effects in Sporothrix schenckii inactivation in vivo
Guirado, Gunther Monteiro de Paula; Feitosa, Luciano dos Santos; Kozusny-Andreani, Dora Inés; Navarro, Ricardo Scarparo.
Afiliação
  • Guirado, Gunther Monteiro de Paula; Brasil University. Biomedical Engineering Program. São Paulo. BR
  • Feitosa, Luciano dos Santos; Federal University of São Paulo. Department of Microbiology and Immunology. São Paulo. BR
  • Kozusny-Andreani, Dora Inés; Brasil University. Ambiental Sciences Program. Fernandópolis. BR
  • Navarro, Ricardo Scarparo; Brasil University. Biomedical Engineering Program. São Paulo. BR
Res. Biomed. Eng. (Online) ; 34(2): 93-101, Apr.-June 2018. graf
Article em En | LILACS | ID: biblio-956290
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Introduction Sporotrichosis is a common disease in tropical regions, caused by the fungus Sporothrix schenckii, affecting mainly rural workers and in direct contact with animals. Although treatment by indiscriminate use of oral antifungal drugs gives rise resistant isolates, leading to therapeutic failures and no remission of the disease. To evaluate the effectiveness of red low-power laser photobiomodulation in inactivation of S. schenckii infection induced in rodents. Methods Subcutaneously inoculation (2x103 S. schenckii/ml, 0.2 ml suspension) in the left footpad, in 27 mice divided into control (n = 6, inoculated, without irradiation) early stage (not inoculated) = 1th biopsy; intermediate (9 weeks of evolution) = 2nd biopsy; final (21 weeks of evolution) = 3th biopsy. Treated (n = 21, inoculated and irradiated) early (13 weeks of evolution, 4 weeks after first irradiation) = 4th biopsy, intermediate (17 weeks of evolution, 8 weeks after first irradiation) = 5th biopsy, final (21 weeks of evolution, 12 weeks after first irradiation) = 6th biopsy. Serial irradiation with biopsies occurred every 30 days during each month, for three months. At the end of testing, the mice were euthanized, and histological analyzes of biopsies were performed. Results Each laser treatment session showed an inactivation of S. schenckii in treated animals compared to controls, with a regression of pseudoepitheliomatous hyperplasia, chronic inflammation, neutrophils, granulomas, giant mononuclear cells and steroid corpuscles. Conclusion The laser photobiomodulation was effective on S. schenckii inactivation, appearing to be an interesting therapeutic option in infections caused by this organism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Res. Biomed. Eng. (Online) Assunto da revista: Engenharia Biom‚dica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Res. Biomed. Eng. (Online) Assunto da revista: Engenharia Biom‚dica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil