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Heterologous fibrin sealant derived from snake venom: from bench to bedside - an overview
Ferreira Jr, Rui Seabra; Barros, Luciana Curtolo de; Abbade, Luciana Patrícia Fernandes; Barraviera, Silvia Regina Catharino Sartori; Silvares, Maria Regina Cavariani; Pontes, Leticia Gomes de; Santos, Lucilene Delazari dos; Barraviera, Benedito.
Afiliação
  • Ferreira Jr, Rui Seabra; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Barros, Luciana Curtolo de; São Paulo State University. Center for the Study of Venoms and Venomous Animals. Botucatu. BR
  • Abbade, Luciana Patrícia Fernandes; São Paulo State University. Botucatu Medical School. Department of Dermatology and Radiology. Botucatu. BR
  • Barraviera, Silvia Regina Catharino Sartori; São Paulo State University. Botucatu Medical School. Department of Dermatology and Radiology. Botucatu. BR
  • Silvares, Maria Regina Cavariani; São Paulo State University. Botucatu Medical School. Department of Dermatology and Radiology. Botucatu. BR
  • Pontes, Leticia Gomes de; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Santos, Lucilene Delazari dos; São Paulo State University. Botucatu Medical School. Botucatu. BR
  • Barraviera, Benedito; São Paulo State University. Botucatu Medical School. Botucatu. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;23: 21, 2017. tab, graf, ilus
Article em En | LILACS, VETINDEX | ID: biblio-954833
Biblioteca responsável: BR68.1
ABSTRACT
Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Venenos de Serpentes / Fibrinogênio / Adesivo Tecidual de Fibrina / Serina Proteases Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Venenos de Serpentes / Fibrinogênio / Adesivo Tecidual de Fibrina / Serina Proteases Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil