Your browser doesn't support javascript.
loading
TGF-ß1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma
Chen, Yijie; Ma, Lin; He, Qian; Zhang, Shaobo; Zhang, Chenghua; Jia, Wei.
Afiliação
  • Chen, Yijie; 180th Hospital of People's Liberation Army. Fujian. CN
  • Ma, Lin; Eighth People's Hospital of Qingdao. Department of General Surgery. Qingdao. CN
  • He, Qian; 180th Hospital of People's Liberation Army. Fujian. CN
  • Zhang, Shaobo; 180th Hospital of People's Liberation Army. Fujian. CN
  • Zhang, Chenghua; 180th Hospital of People's Liberation Army. Fujian. CN
  • Jia, Wei; Tianjin Medical University General Hospital. Department of Emergency Medicine. Tianjin. CN
Biol. Res ; 48: 1-5, 2015. ilus, graf, tab
Article em En | LILACS | ID: biblio-950790
Biblioteca responsável: CL1.1
ABSTRACT

BACKGROUND:

Transforming growth factor (TGF)-ß is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-ß1) expression and prognosis in intrahepatic cholangiocarcinoma

RESULTS:

We examined the expression of TGF-ß1 in 78 intrahepatic cholangiocarcinomas by immunohistochemistry and correlated the expression with clinicopathological parameters. TGF-ß1 was expressed in 37 of 78 (47.4 %) intrahepatic cholangiocarcinomas. The expression of TGF-ß1 was significantly correlated with lymph node metastasis, distant metastasis, and tumour recurrence. Patients with TGF-ß1-positive tumours had significantly shorter survival time. In a multivariant analysis, the expression of TGF-ß1 and the tumour stage were independent prognostic factors

CONCLUSIONS:

Our data suggest that expression of TGF-ß1 is a novel prognostic marker for intrahepatic cholangiocarcinoma.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Colangiocarcinoma / Fator de Crescimento Transformador beta1 / Neoplasias Hepáticas / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Biol. Res Assunto da revista: BIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Colangiocarcinoma / Fator de Crescimento Transformador beta1 / Neoplasias Hepáticas / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Biol. Res Assunto da revista: BIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Chile