Extraocular retinoblastoma: A 13-year experience
CancerCancer
; 98(6): 1292-1298, 2003.
Article
em En
| ColecionaSUS
| ID: biblio-944992
Biblioteca responsável:
BR440.1
Localização: BR440.1
ABSTRACT
The current study was performed to evaluate two regimens of treatment and to describe clinical and epidemiologic characteristics in patients with extraocular retinoblastoma. Eighty-three patients with extraocular retinoblastoma according to Childrens Cancer Group (CCG) classification were admitted to the Pediatric Department of the A. C. Camargo between 1987-2000. The age, gender, race, lag time, first clinical presentation, staging, laterality, and treatment regimen were analyzed. Treatment was comprised of cisplatin, teniposide, vincristine, doxorubicin, and cyclophosphamide during the first treatment period (1987-1991) or cisplatin and teniposide with alternating courses of ifosfamide and etoposide during the second treatment period (1992-2000). The mean age of the patients was 32.9 months (range, 2-145 months). The mean lag time was 10.5 months. Forty-three patients were treated in the first period and 40 patients were treated in the second period. Locally advanced tumors (Class I-III) were present in 83.1% of the patients. There was a positive correlation between lag time and age for unilateral tumors (correlation coefficient [r] = 0.35; P = 0.006), whereas the correlation was negative for bilateral tumors (r = -0.12; P = 0.63). The 5-year overall survival was 55.1% in the first treatment period and 59.4% in the second treatment period (P = 0.69).
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Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
ColecionaSUS
Assunto principal:
Retinoblastoma
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Quimioterapia Combinada
Tipo de estudo:
Clinical_trials
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Prognostic_studies
Limite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
CancerCancer
Ano de publicação:
2003
Tipo de documento:
Article