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Histological studies on the retina and cerebellum of Wistar rats treated with ArteetherTM
Okunlola, A. I; Okunlola, C. K; Okani, C. O; Adewole, O. S; Ofusori, D. A; Komolafe, O. A; Ojo, S. K; Bejide, R. A; Ayoka, A. O; Ojewole, J. A. O.
Afiliação
  • Okunlola, A. I; University College Hospital. Department of Surgery. Ibadan. NG
  • Okunlola, C. K; University College Hospital. Department of Surgery. Ibadan. NG
  • Okani, C. O; University College Hospital. Department of Pathology. Ibadan. NG
  • Adewole, O. S; Obafemi Awolowo University. Department of Anatomy and Cell Biology. Ile-Ife. NG
  • Ofusori, D. A; Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. Department of Anatomy and Cell Biology. Ile-Ife. NG
  • Komolafe, O. A; Obafemi Awolowo University. Department of Anatomy and Cell Biology,. Ile-Ife. NG
  • Ojo, S. K; Obafemi Awolowo University. Department of Anatomy and Cell Biology. Ile-Ife. NG
  • Bejide, R. A; Obafemi Awolowo University. Department of Morbid Anatomy and Forensic Medicine. Ile-Ife. NG
  • Ayoka, A. O; Obafemi Awolowo University. Department of Physiological Sciences. Ile-Ife. NG
  • Ojewole, J. A. O; University of KwaZulu-Natal. College of Health Sciences. School of Nursing and Public Health. Durban. ZA
Braz. j. morphol. sci ; 31(1): 28-32, 1/3/2014. ilus
Article em En | LILACS | ID: biblio-911265
Biblioteca responsável: BR1.1
ABSTRACT

Introduction:

Arteether TM, a derivative of artemisinin, is among the recent drugs that have given renewed hope for combating malarial menace. The present study investigated the effects of arteetherTM on the histology of the retina and cerebellum of Wistar rats. Materials and

Methods:

Twenty adult albino Wistar rats weighing 150-200 g, were randomly divided into four groups (A, B, C and D) of five animals each and used for this study. Group A rats were given intramuscular (i.m.) arteetherTM (3 mg/kg b.w.) daily for 3 days. Group B rats were given i.m. arteetherTM (6 mg/kg b.w.) daily for 3 days. Group C rats were also given i. m. of arteetherTM (3 mg/kg b. w.) daily for 3 days, and the same dose was repeated at two-weekly intervals for 4 further weeks; while Group D rats which received normal saline (0.9 % w/v, 3 ml/kg b.w.), served as controls. At the end of the experiment, the rats were sacrificed by cervical dislocation. The retina and cerebellum were excised and processed routinely for histopathology changes, using haematoxylin and eosin stain (H & E), as well as Nissl stain.

Results:

Results obtained showed normal cellular components of the retina and cerebellum in all groups, and no cyto-pathological changes were observed.

Conclusion:

Thus, this study showed that under light microscopic examination, therapeutic doses of arteetherTM caused no significant cyto-pathologic changes in the retina and cerebellum of Wistar rats.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Retina / Cerebelo / Artemisininas / Malária Limite: Animals Idioma: En Revista: Braz. j. morphol. sci Assunto da revista: ANATOMIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Nigéria / África do Sul País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Retina / Cerebelo / Artemisininas / Malária Limite: Animals Idioma: En Revista: Braz. j. morphol. sci Assunto da revista: ANATOMIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Nigéria / África do Sul País de publicação: Brasil