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Systemic effect of mineral aggregate-based cements: histopathological analysis in rats
Garcia, Lucas da Fonseca Roberti; Huck, Claudia; Magalhães, Fernando Augusto Cintra; Souza, Pedro Paulo Chaves de; Souza Costa, Carlos Alberto de.
Afiliação
  • Garcia, Lucas da Fonseca Roberti; Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Departamento de Odontologia. Florianópolis. BR
  • Huck, Claudia; Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Departamento de Odontologia. Florianópolis. BR
  • Magalhães, Fernando Augusto Cintra; Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Departamento de Odontologia. Florianópolis. BR
  • Souza, Pedro Paulo Chaves de; Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Departamento de Odontologia. Florianópolis. BR
  • Souza Costa, Carlos Alberto de; Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Departamento de Odontologia. Florianópolis. BR
J. appl. oral sci ; J. appl. oral sci;25(6): 620-630, Nov.-Dec. 2017. tab, graf
Article em En | LILACS, BBO | ID: biblio-893669
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Objective:

Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. Material and

Methods:

Samples of Mineral Trioxide Aggregate (MTA) and a calcium aluminate-based cement (EndoBinder) containing different radiopacifiers were implanted into the dorsum of 40 rats. After 7 and 30 d, samples of subcutaneous, liver and kidney tissues were submitted to histopathological analysis. A score (0-3) was used to grade the inflammatory reaction. Blood samples were collected to evaluate changes in hepatic and renal functions of animals.

Results:

The moderate inflammatory reaction (2) observed for 7 d in the subcutaneous tissue decreased with time for all cements. The thickness of inflammatory capsules also presented a significant decrease with time (P<.05). Systemically, all cements caused adverse inflammatory reactions in the liver and kidney, being more evident for MTA, persisting until the end of the analysis. Liver functions increased significantly for MTA during 30 d (P<.05).

Conclusion:

The different cements induced to a locally limited inflammatory reaction. However, from the systemic point of view, the cements promoted significant inflammatory reactions in the liver and kidney. For MTA, the reactions were more accentuated.
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Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Óxidos / Materiais Restauradores do Canal Radicular / Silicatos / Compostos de Cálcio / Compostos de Alumínio / Cimentos Dentários / Rim / Fígado Limite: Animals Idioma: En Revista: J. appl. oral sci Assunto da revista: ODONTOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Óxidos / Materiais Restauradores do Canal Radicular / Silicatos / Compostos de Cálcio / Compostos de Alumínio / Cimentos Dentários / Rim / Fígado Limite: Animals Idioma: En Revista: J. appl. oral sci Assunto da revista: ODONTOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil