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Inhibitory effect of Dendrobium officinale polysaccharide on human gastric cancer cell xenografts in nude mice
ZHANG, Liying; WANG, Fabao; REN, Xiubao.
Afiliação
  • ZHANG, Liying; Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center for Cancer. Department of Biotherapy. Tianjin. CN
  • WANG, Fabao; Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center for Cancer. Department of Biotherapy. Tianjin. CN
  • REN, Xiubao; Tianjin Medical University Cancer Institute and Hospital. National Clinical Research Center for Cancer. Department of Biotherapy. Tianjin. CN
Food Sci. Technol (SBCTA, Impr.) ; Food Sci. Technol (SBCTA, Impr.);38(1): 78-83, Jan.-Mar. 2018. tab
Article em En | LILACS | ID: biblio-892251
Biblioteca responsável: BR25.1
ABSTRACT
Abstract This study investigated the inhibitory effect of Dendrobium officinale polysaccharide (DOPA) on human gastric cancer cell SGC-7901 xenografts in nude mice. The nude mice with SGC-7901 xenografts were randomly divided into model, 5-fluorouracil (5-Fu), low-dose DOPA, middle-dose DOPA and high-dose DOPA group. The later four groups were intragastrically administrated with 100, 200 and 400 mg·kg-1·day-1 DOPA, 400 mg·kg-1·day-1 5-Fu and normal saline, respectively. After treatment for 20 days, the tumor inhibition rate of in high-dose DOPA group was basically equivalent to 5-Fu group. Compared with 5-Fu, DOPA had no obvious toxic side effect on spleen or thymus indexes, routine blood indexes or liver and kidney functions of nude mice. Compared with model group, the serum tumor necrosis factor-α and interleukin-2 levels in middle- and high-dose DOPA group were significantly increased (P < 0.05), Bax protein expression was significantly increased (P < 0.05), and Bcl-2 protein expression was significantly decreased (P < 0.05). DOPA can inhibit the growth of SGC-7901 cell xenografts in nude mice. The mechanism may be related to its increase of serum TNF-α and IL-2 levels, up-regulation of Bax protein expression and down-regulation of Bcl-2 protein expression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Gástricas / Ensaios Antitumorais Modelo de Xenoenxerto Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Food Sci. Technol (SBCTA, Impr.) Assunto da revista: ALIMENTOS / CIENCIAS DA NUTRICAO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias Gástricas / Ensaios Antitumorais Modelo de Xenoenxerto Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Food Sci. Technol (SBCTA, Impr.) Assunto da revista: ALIMENTOS / CIENCIAS DA NUTRICAO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Brasil