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Serum 25-hydroxyvitamin D levels in patients with Granulomatosis with Polyangiitis: association with respiratory infection
Perez, Mariana O; Oliveira, Ricardo M; Levy-Neto, Mauricio; Caparbo, Valeria F; Pereira, Rosa M R.
Afiliação
  • Perez, Mariana O; Universidade de São Paulo. Faculdade de Medicina FMUSP. Divisao de Reumatologia. Sao Paulo. BR
  • Oliveira, Ricardo M; Universidade de São Paulo. Faculdade de Medicina FMUSP. Divisao de Reumatologia. Sao Paulo. BR
  • Levy-Neto, Mauricio; Universidade de São Paulo. Faculdade de Medicina FMUSP. Divisao de Reumatologia. Sao Paulo. BR
  • Caparbo, Valeria F; Universidade de São Paulo. Faculdade de Medicina FMUSP. Divisao de Reumatologia. Sao Paulo. BR
  • Pereira, Rosa M R; Universidade de São Paulo. Faculdade de Medicina FMUSP. Divisao de Reumatologia. Sao Paulo. BR
Clinics ; Clinics;72(12): 723-728, Dec. 2017. tab, graf
Article em En | LILACS | ID: biblio-890695
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

To determine the possible association of serum 25-hydroxyvitamin D (25OHD) levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods winter/spring and summer/autumn.

METHODS:

Thirty-two granulomatosis with polyangiitis patients were evaluated in the winter/spring, and the same patients (except 5) were evaluated in summer/autumn (n=27). The 25OHD levels were measured by radioimmunoassay. Disease activity was assessed by the Birmingham Vasculitis Activity Score Modified for Wegener's Granulomatosis (BVAS/WG) and antineutrophil cytoplasmic antibody (ANCA) positivity. Respiratory infection was defined according the Centers for Disease Control and Prevention criteria.

RESULTS:

25OHD levels were lower among patients in winter/spring than in summer/autumn (32.31±13.10 vs. 38.98±10.97 ng/mL, p=0.04). Seven patients met the criteria for respiratory infection 5 in winter/spring and 2 in summer/autumn. Patients with respiratory infection presented lower 25OHD levels than those without infection (25.15±11.70 vs. 36.73±12.08 ng/mL, p=0.02). A higher frequency of low vitamin D levels (25OHD<20 ng/mL) was observed in patients with respiratory infection (37.5% vs. 7.8, p=0.04). Serum 25OHD levels were comparable between patients with (BVAS/WG≥1 plus positive ANCA) and without disease activity (BVAS/WG=0 plus negative ANCA) (35.40±11.48 vs. 35.34±13.13 ng/mL, p=0.98).

CONCLUSIONS:

Lower 25OHD levels were associated with respiratory infection but not disease activity in granulomatosis with polyangiitis patients. Our data suggest that hypovitaminosis D could be an important risk factor for respiratory infection in granulomatosis with polyangiitis patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções Respiratórias / Estações do Ano / Vitamina D / Granulomatose com Poliangiite Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções Respiratórias / Estações do Ano / Vitamina D / Granulomatose com Poliangiite Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil