Your browser doesn't support javascript.
loading
Assessing endocrine and immune parameters in human immunodeficiency virus-infected patients before and after the immune reconstitution inflammatory syndrome
Rateni, Liliana; Lupo, Sergio; Racca, Liliana; Palazzi, Jorge; Ghersevich, Sergio.
Afiliação
  • Rateni, Liliana; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario. AR
  • Lupo, Sergio; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario. AR
  • Racca, Liliana; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario. AR
  • Palazzi, Jorge; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario. AR
  • Ghersevich, Sergio; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario. AR
Arch. endocrinol. metab. (Online) ; 62(1): 64-71, Jan.-Feb. 2018. tab, graf
Article em En | LILACS | ID: biblio-887635
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Objective The present study compares immune and endocrine parameters between HIV-infected patients who underwent the Immune Reconstitution Inflammatory Syndrome (IRIS-P) during antiretroviral therapy (ART) and HIV-patients who did not undergo the syndrome (non-IRIS-P). Materials and methods Blood samples were obtained from 31 HIV-infected patients (15 IRIS-P and 16 non-IRIS-P) before ART (BT) and 48 ± 2 weeks after treatment initiation (AT). Plasma Interleukin-6 (IL-6) and Interleukin-18 (IL-18) were determined by ELISA. Cortisol, dehydroepiandrosterone sulfate (DHEA-S) and thyroxin concentrations were measured using chemiluminescence immune methods. Results Concentrations of IL-6 (7.9 ± 1.9 pg/mL) and IL-18 (951.5 ± 233.0 pg/mL) were significantly higher (p < 0.05) in IRIS-P than in non-IRIS-P (3.9 ± 1.0 pg/mL and 461.0 ± 84.4 pg/mL, respectively) BT. Mean T4 plasma level significantly decreased in both groups of patients after treatment (p < 0.05). In both groups cortisol levels were similar before and after ART (p > 0.05). Levels of DHEA-S in IRIS-P decreased AT (1080.5 ± 124.2 vs. 782.5 ± 123.8 ng/mL, p < 0.05) and they were significantly lower than in non-IRIS-P (782.5 ± 123.8 vs. 1203.7 ± 144.0 ng/mL, p < 0.05). IRIS-P showed higher values of IL-6 and IL-18 BT and lower levels of DHEA-S AT than in non-IRIS-P. Conclusion These parameters could contribute to differentiate IRIS-P from non-IRIS-P. The significant decrease in DHEA-S levels in IRIS-P after ART might suggest a different adrenal response in these patients, which may reflect the severity of the disease.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Biomarcadores / Infecções por HIV / Terapia Antirretroviral de Alta Atividade / Síndrome Inflamatória da Reconstituição Imune Tipo de estudo: Observational_studies Limite: Female / Humans / Male Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Biomarcadores / Infecções por HIV / Terapia Antirretroviral de Alta Atividade / Síndrome Inflamatória da Reconstituição Imune Tipo de estudo: Observational_studies Limite: Female / Humans / Male Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Brasil