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Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes
Ademoglu, Esra Nur; Gorar, Suheyla; Keskin, Muge; Carlioglu, Ayse; Ucler, Rifki; Erdamar, Husamettin; Culha, Cavit; Aral, Yalcin.
Afiliação
  • Ademoglu, Esra Nur; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Gorar, Suheyla; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Keskin, Muge; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Carlioglu, Ayse; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Ucler, Rifki; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Erdamar, Husamettin; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Culha, Cavit; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
  • Aral, Yalcin; Bolu University. Department of Endocrinology and Metabolism. Bolu. TR
Arch. endocrinol. metab. (Online) ; 61(5): 455-459, Sept.-Oct. 2017. tab, graf
Article em En | LILACS | ID: biblio-887598
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Objective To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteínas de Ligação ao Cálcio / Diabetes Gestacional / Proteínas de Ligação a DNA / Proteínas do Tecido Nervoso Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteínas de Ligação ao Cálcio / Diabetes Gestacional / Proteínas de Ligação a DNA / Proteínas do Tecido Nervoso Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil