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Deaths related to differentiated thyroid cancer: a rare but real event
Leite, Ana Kober N; Cavalheiro, Beatriz G; Kulcsar, Marco Aurélio; Hoff, Ana de Oliveira; Brandão, Lenine G; Cernea, Claudio Roberto; Matos, Leandro L.
Afiliação
  • Leite, Ana Kober N; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Cavalheiro, Beatriz G; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Kulcsar, Marco Aurélio; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Hoff, Ana de Oliveira; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Brandão, Lenine G; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Cernea, Claudio Roberto; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Matos, Leandro L; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
Arch. endocrinol. metab. (Online) ; 61(3): 222-227, May-June 2017. tab, graf
Article em En | LILACS | ID: biblio-887555
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Objective The present study describes the clinical and tumor characteristics of patients that died from differentiated thyroid cancer and reports on the cause and circumstances of death in these cases. Subjects and methods Retrospective analysis of all the differentiated thyroid cancer (DTC) related deaths at a single institution over a 5-year period, with a total of 33 patients. Results Most of the patients were female (63.6%), with a mean age at diagnosis of 58.2 years. The most common histologic type was papillary (66.7%) and 30.3% were follicular. The distribution according to the TNM classification was 15.4% of T1; 7.7% T2; 38.4% T3; 19.2% of T4a and 19.2% of T4b. Forty-four percent of cases were N0; 20% N1a and 36.6% of N1b. Twelve patients were considered non-responsive to radioiodine. Only one of the patients did not have distant metastases. The most common metastatic site was the lung in 69.7%. The majority of deaths were due to pulmonary complications related to lung metastases (17 patients, 51.5%), followed by post-operative complications in 5 cases, neurological disease progression in 3 cases, local invasion and airway obstruction in one patient. Median survival between diagnosis and death was reached in 49 months while between disease progression and death it was at 22 months. Conclusion Mortality from DTC is extremely rare but persists, and the main causes of death derive from distant metastasis, especially respiratory failure due to lung metastasis. Once disease progression is established, median survival was only 22 months.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias da Glândula Tireoide / Carcinoma Papilar / Adenocarcinoma Folicular Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias da Glândula Tireoide / Carcinoma Papilar / Adenocarcinoma Folicular Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil