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Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy
Gozeneli, Orhan; Tatli, Faik; Gunes, Ali Erdal; Guldur, Muhammed Emin; Taskin, Abdullah; Bardakci, Osman; Yilmaz, Mehmet.
Afiliação
  • Gozeneli, Orhan; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
  • Tatli, Faik; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
  • Gunes, Ali Erdal; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
  • Guldur, Muhammed Emin; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
  • Taskin, Abdullah; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
  • Bardakci, Osman; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
  • Yilmaz, Mehmet; Harran University. Faculty of Medicine. Department of General Surgery. Sanliurfa. TR
Acta cir. bras ; Acta cir. bras;33(2): 110-116, Feb. 2018. tab, graf
Article em En | LILACS | ID: biblio-886264
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver.

Methods:

Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis.

Results:

Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3.

Conclusions:

Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin.
Assuntos
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Regeneração Hepática / Antioxidantes Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Regeneração Hepática / Antioxidantes Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil