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Evaluation of antioxidant efficacy of Purslane extract in Patients with Recurrent Aphthous Stomatitis: a randomized, placebo-controlled, triple-blinded, clinical trial
Mohammadzadeh, Mahsa; Rezaei, Nima; Kamran, Elnaz; Abdolhoseinpour, Faraneh; Mohammadzadeh, Mohsen; Moqadam, Isaac Firooze; Najafi, Shamsolmoulouk; Ahmadabadi, Mohsen Hoseini.
Afiliação
  • Mohammadzadeh, Mahsa; Islamic Azad University. Dental Branch. Tehran. IR
  • Rezaei, Nima; Tehran University of Medical Sciences. Children's Medical Center. Research Center for Immunodeficiencies. Tehran. IR
  • Kamran, Elnaz; Islamic Azad University. Dental Branch. Tehran. IR
  • Abdolhoseinpour, Faraneh; Islamic Azad University. Dental Branch. Tehran. IR
  • Mohammadzadeh, Mohsen; North-Khorasan university of medical sciences. Bojnourd. IR
  • Moqadam, Isaac Firooze; Periodontist. Private practice. IR
  • Najafi, Shamsolmoulouk; Tehran University of Medical Sciences. School of Dentistry. Dental Research Center, Department of Oral Medicine. Tehran. IR
  • Ahmadabadi, Mohsen Hoseini; Tehran University of Medical Sciences. Chimist,pharmacy. Tehran. IR
Braz. j. oral sci ; 15(3)July-Sept. 2016. tab
Article em En | LILACS, BBO | ID: biblio-875097
Biblioteca responsável: BR218.1
ABSTRACT

Background:

This herbal medicine is considered a rich source of antioxidants with anti-inflammatory effects. The purpose of this study was to evaluate the effectiveness of purslane in treatment of recurrent aphthous stomatitis (RAS) and also it ̓s effect on antioxidant level. Materials and

methods:

50 patients were selected for this randomized triple-blind placebo-controlled trial. All subjects were randomly divided in to two groups, one group received purslane (n=25) and another group, placebo (n=25) for 3 month. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and total antioxidant status (TAS) was measured in plasma at baseline and after 3 month of treatment. Also pain intensity based on the visual analogue scale (VAS), the mean interval between lesion, number of lesions and the mean duration of complete healing at baseline and in month 1, 2 and 3 were recorded. Statistical analysis was performed by using Mann-Whitney and T-test.

Results:

A significant decrease in pain intensity in VAS scores was seen after treatment in intervention group (p<0.001). The mean duration of complete healing showed significant differences (P<0.001) between the two groups. The mean interval between lesions also showed significant differences (P<0.001) among the intervention group (33.12 days) compared with the placebo group (17.88 days). No significant differences were found regarding the number of lesions, level of erythrocyte GSHPx, TAS and SOD. No serious side-effects occurred in either of groups.

Conclusions:

According to this study, purslane is clinically effective in treatment of RAS (number of lesions, pain intensity and duration of healing) although it is unable to change the level of antioxidants. (AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Estomatite Aftosa / Estatísticas não Paramétricas / Antioxidantes Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. oral sci Assunto da revista: ODONTOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: BBO / LILACS Assunto principal: Estomatite Aftosa / Estatísticas não Paramétricas / Antioxidantes Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. oral sci Assunto da revista: ODONTOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil