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Alterations in the hypothalamic­pituitary­thyroid axis in animals submitted to early-life trauma
Machado, Tania Diniz; Molle, Roberta Dalle; Silveira, Patrícia Pelufo.
Afiliação
  • Machado, Tania Diniz; Universidade Federal do Rio Grande do Sul. School of Medicine. Post-graduate Program in Child and Adolescent Health. Porto Alegre. BR
  • Molle, Roberta Dalle; Universidade Federal do Rio Grande do Sul. School of Medicine. Post-graduate Program in Child and Adolescent Health. Porto Alegre. BR
  • Silveira, Patrícia Pelufo; Universidade Federal do Rio Grande do Sul. School of Medicine. Post-graduate Program in Child and Adolescent Health. Porto Alegre. BR
Clin. biomed. res ; 37(3): 169-174, 2017. graf, tab
Article em En | LILACS | ID: biblio-859828
Biblioteca responsável: BR18.1
Localização: BR18.1
ABSTRACT

Introduction:

Changes in maternal care can affect offspring's thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.

Methods:

From the second day of life, litters of Wistar rats were subjected to reduced nesting material (Early­Life Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.

Results:

Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.

Conclusion:

The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption (AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Sistema Hipófise-Suprarrenal / Estresse Psicológico / Glândula Tireoide / Sistema Hipotálamo-Hipofisário / Comportamento Materno Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin. biomed. res Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Sistema Hipófise-Suprarrenal / Estresse Psicológico / Glândula Tireoide / Sistema Hipotálamo-Hipofisário / Comportamento Materno Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin. biomed. res Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil