Alterations in the hypothalamicpituitarythyroid axis in animals submitted to early-life trauma
Clin. biomed. res
; 37(3): 169-174, 2017. graf, tab
Article
em En
| LILACS
| ID: biblio-859828
Biblioteca responsável:
BR18.1
Localização: BR18.1
ABSTRACT
Introduction:
Changes in maternal care can affect offspring's thyroid hormone T3 levels. Pups from highly caring mothers have higher levels of thyroid hormone T3. In humans, physical abuse in childhood is related to lower levels of T3 in adolescence. This study aimed at verifying if early-life trauma in rodents is correlated with T3 levels in adulthood.Methods:
From the second day of life, litters of Wistar rats were subjected to reduced nesting material (EarlyLife Stress-ELS) or standard care (Controls). In adult life, the animals were chronically exposed to standard diet or standard diet + palatable diet and plasma T3 levels were measured before and after the exposition to diet.Results:
Thyroid hormone T3 levels in adult life correlated negatively with the licking and grooming (LG) scores in the ELS group. This correlation disappeared when the animals had the opportunity to choose between two diets chronically.Conclusion:
The adverse environment affected maternal behavior and caused marks on the metabolism of the intervention group (T3), which were reverted by chronic palatable food consumption (AU)Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Sistema Hipófise-Suprarrenal
/
Estresse Psicológico
/
Glândula Tireoide
/
Sistema Hipotálamo-Hipofisário
/
Comportamento Materno
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Clin. biomed. res
Assunto da revista:
MEDICINA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil