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GOLD 2011 A-D CHART under the microscope: Responding to COPD physiopathogeny with implications in disease management
Uribe Echevarría, Loli; García González, Jorge; Nevado, Alberto; Álvarez, Ruth; Maldonado, Cristina.
Afiliação
  • Uribe Echevarría, Loli; Sanatorio Allende. Pneomonology Department. Nueva Córdoba. AR
  • García González, Jorge; Sanatorio Allende. Pneomonology Department. Nueva Córdoba. AR
  • Nevado, Alberto; Sanatorio Allende. Pneomonology Department. Nueva Córdoba. AR
  • Álvarez, Ruth; Centro de Deshabituación Tabáquica Nuevo Hospital San Roque. Córdoba. AR
  • Maldonado, Cristina; Centro de Microscopia Electrónica. Córdoba. AR
Rev. am. med. respir ; 17(1): 77-82, mar. 2017. graf, tab
Article em En | LILACS | ID: biblio-843036
Biblioteca responsável: AR423.1
ABSTRACT
The purpose of this study was to analyze sputum cellular phenotype in patients with a diagnosis of COPD classified according to the A-D chart. We included patients of both genders, aged ≥ 60 years, who were former smokers of at least 10 packets/year, with a diagnosis of COPD under stable conditions. They were classified according to the 2011 GOLD criteria into clinical categories A, B, C, D and their bronchial inflammatory pattern was analyzed using sputum cytology. Eighty-five patients with a diagnosis of COPD were divided into category A (19), B (29), C (19) and D (18); the age of the latter was significantly higher than the rest of the patients. The predominant cellular pattern in sputum was eosinophilic (43), neutrophilic (17), mixed (9) and paucigranulocytic (16). The distribution of the predominant cellular pattern in connection with each COPD clinical group was statistically significant p ≤ 0.001. The neutrophilic cellular phenotype was predominant in group A; the eosinophilic and mixed phenotypes in groups B and C, and in group D, even though eosinophils were present, the predominant pattern was neutrophilic. We concluded that this study identified inflammatory cellular patterns that distinguish each group in the COPD A-D chart, which can contribute to explain their heterogeneous nature, customize treatment and, most of all, identify patients at risk of disease onset and perpetuation at an early stage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Terapêutica / Classificação / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Prognostic_studies Idioma: En Revista: Rev. am. med. respir Assunto da revista: MEDICINA / PNEUMOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Argentina
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Terapêutica / Classificação / Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Prognostic_studies Idioma: En Revista: Rev. am. med. respir Assunto da revista: MEDICINA / PNEUMOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Argentina