Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;50(6): e6104, 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-839305
Biblioteca responsável:
BR1.1
ABSTRACT
Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Neoplasias Ovarianas
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Biomarcadores Tumorais
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Metaloproteinases da Matriz
Limite:
Female
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Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2017
Tipo de documento:
Article
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Project document
País de afiliação:
China
País de publicação:
Brasil