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Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis
Lu, W; Kang, J; Hu, K; Tang, S; Zhou, X; Yu, S; Xu, L.
Afiliação
  • Lu, W; Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Kang, J; Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Hu, K; Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Tang, S; Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Zhou, X; Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Yu, S; Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Xu, L; Wuhan University. Division of Respiratory Disease. Wuhan. CN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;50(1): e5594, 2017. graf
Article em En | LILACS | ID: biblio-839239
Biblioteca responsável: BR1.1
ABSTRACT
We aimed to study the renal injury and hypertension induced by chronic intermittent hypoxia (CIH) and the protective effects mediated by angiotensin 1-7 [Ang(1-7)]. We randomly assigned 32 male Sprague-Dawley rats (body weight 180-200 g) to normoxia control, CIH, Ang(1-7)-treated normoxia, and Ang(1-7)-treated CIH groups. Systolic blood pressure (SBP) was monitored at the start and end of each week. Renal sympathetic nerve activity (RSNA) was recorded. CTGF and TGF-β were detected by immunohistochemistry and western blotting. Tissue parameters of oxidative stress were also determined. In addition, renal levels of interleukin-6, tumor necrosis factor-α, nitrotyrosine, and hypoxia-inducible factor-1α were determined by immunohistochemistry, immunoblotting, and ELISA. TUNEL assay results and cleaved caspase 3 and 12 were also determined. Ang(1-7) induced a reduction in SBP together with a restoration of RSNA in the rat model of CIH. Ang(1-7) treatment also suppressed the production of reactive oxygen species, reduced renal tissue inflammation, ameliorated mesangial expansion, and decreased renal fibrosis. Thus, Ang(1-7) treatment exerted renoprotective effects on CIH-induced renal injury and was associated with a reduction of oxidative stress, inflammation and fibrosis. Ang(1-7) might therefore represent a promising therapy for obstructive sleep apnea-related hypertension and renal injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Fragmentos de Peptídeos / Angiotensina I / Estresse Oxidativo / Injúria Renal Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Fragmentos de Peptídeos / Angiotensina I / Estresse Oxidativo / Injúria Renal Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil