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Usefulness of diffusion tensor imaging in amyotrophic lateral sclerosis: potential biomarker and association with the cognitive profile / Utilidad del tensor de difusión en esclerosis lateral amiotrofica: potencial biomarcador y asociación con el perfil cognitivo
Chaves, Marcelo; Bettini, Mariela; Fernandez, Maria Cecilia; Basalo, Maria Jose Garcia; Rojas, Juan Ignacio; Besada, Cristina; Cristiano, Edgardo; Golimstok, Angel; Rugiero, Marcelo.
Afiliação
  • Chaves, Marcelo; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Bettini, Mariela; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Fernandez, Maria Cecilia; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Basalo, Maria Jose Garcia; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Rojas, Juan Ignacio; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Besada, Cristina; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Cristiano, Edgardo; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Golimstok, Angel; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
  • Rugiero, Marcelo; Hospital Italiano de Buenos Aires. Neurology Department. Buenos Aires City. AR
Arq. neuropsiquiatr ; Arq. neuropsiquiatr;75(5): 272-276, May 2017. tab, graf
Article em En | LILACS | ID: biblio-838901
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT The objective of this preliminary study was to correlate diffusion tensor imaging (DTI) alterations with the cognitive profile of patients with amyotrophic lateral sclerosis (ALS). Methods This was a case-control study conducted from December 1, 2012 to December 1, 2014. Clinical and demographic data were recorded. A neuropsychological test battery adapted to ALS patients was used. An MRI with DTI was performed in all patients and fractional anisotropy (FA) was analyzed in the white matter using the tract based spatial statistics program. Results Twenty-four patients with ALS (15 females, mean age 66.9 + -2.3) and 13 healthy controls (four females, average age 66.9 + - 2) were included. The DTI showed white matter damage in ALS patients vs. healthy controls (p < 0.001). Discussion In our preliminary study the alterations of white matter in DTI were significantly associated with cognitive impairment in patients with ALS.
RESUMEN
RESUMEN El objetivo del presente estudio preliminar fue correlacionar alteraciones del Tensor de Difusión (TD) con el perfil cognitivo de pacientes con Esclerosis Lateral Amiotrofica (ELA). Metodos Se realizó estudio casos-controles entre el 1 de Diciembre del 2012 hasta el 1 de Diciembre del 2014. Se registraron datos clínicos y demográficos. Se utilizó batería de tests neuropsicológicos adaptada a ELA. Se realizó RMN de cerebro con TD en todos los pacientes, la Fracción de Anisotropía (FA) se analizó en sustancia blanca, utilizando el programa Tract Based Spatial Statistics. Resultados Se incluyeron 24 pacientes con ELA (15 mujeres, edad media 66.9 + -2.3) y 13 controles sanos (4 mujeres, edad media 66.9 +-2). El TD mostró daño en sustancia blanca en los pacientes con ELA vs controles (p < 0.001). Discusión En nuestro estudio preliminar las alteraciones de sustancia blanca en TD se asociaron significativamente con alteraciones cognitivas en pacientes con ELA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Imagem de Tensor de Difusão / Disfunção Cognitiva / Substância Branca / Esclerose Lateral Amiotrófica Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Arq. neuropsiquiatr Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Brasil
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Imagem de Tensor de Difusão / Disfunção Cognitiva / Substância Branca / Esclerose Lateral Amiotrófica Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Arq. neuropsiquiatr Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Brasil