Do you know this syndrome? Werner syndrome
An. bras. dermatol
; An. bras. dermatol;92(2): 271-272, Mar.-Apr. 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-838064
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Síndrome de Werner
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Brasil