Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
Acta cir. bras
; Acta cir. bras;32(3): 229-235, Mar. 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-837690
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress.Methods:
Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion.Results:
Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue.Conclusion:
Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Tramadol
/
Traumatismo por Reperfusão
/
Estresse Oxidativo
/
Precondicionamento Isquêmico
/
Substâncias Protetoras
/
Isquemia
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil