Primary myelofibrosis: current therapeutic options
Rev. bras. hematol. hemoter
; Rev. bras. hematol. hemoter;38(3): 257-263, 2016. tabela, figura
Article
em En
| LILACS
| ID: biblio-837123
Biblioteca responsável:
BR408.1
ABSTRACT
Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of proinflammatory cytokines and hepatosplenomegaly frequently impair quality of life. Herein the main current treatment options for primary myelofibrosis patients are discussed, contemplating disease-modifying therapeutics in addition to palliative measures, in an individualized patient-based approach:
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Janus Quinase 2
/
Mielofibrose Primária
/
Transtornos Mieloproliferativos
Aspecto:
Patient_preference
Limite:
Humans
Idioma:
En
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil