Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury
Acta cir. bras
; Acta cir. bras;31(11): 730-735, Nov. 2016. tab, graf
Article
em En
| LILACS
| ID: biblio-827659
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury.METHODS:
Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve Group I ozone (20mcg/ml); Group II methylprednisolone (2mg/kg); Group III ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury.RESULTS:
Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p<0.001) and inflammation in peripheral tissue (p=0.006). Degeneration was remarkably low in Group III, while no change in nerve sheath cell was noted in Group II.CONCLUSION:
The combined use of methylprednisolone and ozone treatment can have beneficial effects for regeneration after crush type nerve injury.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Oxidantes Fotoquímicos
/
Ozônio
/
Nervo Isquiático
/
Metilprednisolona
/
Traumatismos dos Nervos Periféricos
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Brasil