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The effects of fibroblast growth factor-23 on diagnosis of cerebral infarction and vertebral basilar artery stenosis
Wei, Zhuoqun; Zhong, Changyang; Wu, Chunli; Liu, Yuan.
Afiliação
  • Wei, Zhuoqun; Zhejiang Chinese Medical University. Hangzhou. CN
  • Zhong, Changyang; Hangzhou Third Peoples Hospital. Cerebrovascular Disease Department. Hangzhou. CN
  • Wu, Chunli; Hangzhou Third Peoples Hospital. Cerebrovascular Disease Department. Hangzhou. CN
  • Liu, Yuan; Hangzhou Third Peoples Hospital. Cerebrovascular Disease Department. Hangzhou. CN
Clinics ; Clinics;79: 100457, 2024. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1574746
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Objectives:

This study aimed to explore the correlation between Fibroblast Growth Factor-23 (FGF23) levels and Cerebral Infarction (CI), and to determine whether there is a significant relationship between FGF23 and the occurrence and severity of CI.

Methods:

The study categorized Cerebral Infarction (CI) patients into severe and mild stenosis groups based on vertebrobasilar artery stenosis, using Digital Subtraction Angiography (DSA) and Magnetic Resonance Imaging (MRI). The study compared the levels of Fibroblast Growth Factor-23 (FGF23) in the serum of CI patients and healthy controls using a t-test and evaluated the diagnostic effectiveness of serum FGF23 using a Receiver Operating Characteristic (ROC) curve. Additionally, the study analyzed the correlation between FGF23 levels and CI severity after treatment using the National Institute of Health Stroke Scale score.

Results:

The study found a significant increase in serum Fibroblast Growth Factor-23 (FGF23) levels in patients with Cerebral Infarction (CI) compared to healthy volunteers, (p < 0.001). A higher serum FGF23 level was observed in the severe stenosis group than in the mild stenosis group (p < 0.001). Furthermore, the study showed that a high FGF23 level at admission was significantly related to more severe symptoms of CI as indicated by the National Institute of Health Stroke Scale (NIHSS) score on the 7th day after treatment (p < 0.001).

Conclusions:

This study discovered a correlation between Fibroblast Growth Factor-23 (FGF23) levels, vertebroba-silar artery stenosis, and short-term prognosis in patients who had recently experienced acute Cerebral Infarction (CI).
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil