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Diagnostic value of serum inflammatory markers in predicting early refractoriness of transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer Stage 0, A, and B hepatocellular carcinoma
Yang, Junhui; Zhang, Yunjie; Kong, Yifan; Lin, Jiawei; Zhu, Guoqing; Zhang, Hao; Yu, Zhijie; Liu, Pixu; Xia, Jinglin.
Afiliação
  • Yang, Junhui; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
  • Zhang, Yunjie; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
  • Kong, Yifan; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
  • Lin, Jiawei; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
  • Zhu, Guoqing; The First Affiliated Hospital of Wenzhou Medical University. Department of Interventional Radiology. Wenzhou. CN
  • Zhang, Hao; The Wenzhou Central Hospital. Department of Gastroenterology. Wenzhou. CN
  • Yu, Zhijie; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
  • Liu, Pixu; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
  • Xia, Jinglin; First Affiliated Hospital of Wenzhou Medical University. Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation. Wenzhou. CN
Braz. j. med. biol. res ; 57: e13661, fev.2024. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1574240
Biblioteca responsável: BR1.1
ABSTRACT
Transarterial chemoembolization (TACE) is an established therapeutic strategy for intermediate stage Barcelona Clinic Liver Cancer (BCLC) hepatocellular carcinoma (HCC). However, patients who are early refractory to TACE may not benefit from repeated TACE treatment. Our primary objective was to assess the diagnostic value of inflammatory markers in identifying early TACE refractory for patients with early (BCLC 0 and A) or intermediate (BCLC B) stage HCC. We retrospectively reviewed the HCC patients who underwent TACE as the initial treatment in two hospitals. Patients with early TACE refractoriness had significantly poorer median overall survival (OS) (16 vs 40 months, P<0.001) and progression-free survival (PFS) (7 vs 23 months, P<0.001) compared to TACE non-refractory patients. In the multivariate regression analysis, tumor size (P<0.001), bilobular invasion (P=0.007), high aspartate aminotransferase-to-platelet ratio index (APRI) (P=0.007), and high alpha fetoprotein (AFP) level (P=0.035) were independent risk factors for early TACE refractoriness. The predictive model showcasing these factors exhibited high ability proficiency, with an area under curve (AUC) of 0.833 (95%CI=0.774-0.892) in the training cohort, 0.750 (95%CI 0.640-0.861) in the internal-validation cohort, and 0.733 (95%CI 0.594-0.872) in the external-validation cohort. Calibration curve analysis revealed good agreement between the actual and predicted probabilities of early TACE refractoriness. Our preliminary study estimated the potential value of inflammatory markers in predicting early TACE refractoriness and provides a predictive model to assist in identifying patients who may not benefit from repeat TACE treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil