Circulating JKAP levels may correlate with postpartum anxiety and depression through its interaction with T helper 17 cells

Zhang, Jing; Li, Cui; Chen, Zhuo; Zhao, Xiaoling; He, Yuanyuan; Wei, Lei; Kong, Nana

Zhang, Jing; Li, Cui; Chen, Zhuo; Zhao, Xiaoling; He, Yuanyuan; Wei, Lei; Kong, Nana.

Afiliação

Zhang, Jing; Xingtai Peoples Hospital. Department of Obstetrics. Xingtai. CN
Li, Cui; Xingtai Peoples Hospital. Department of Operating Room. Xingtai. CN
Chen, Zhuo; Xingtai Peoples Hospital. Department of Obstetrics. Xingtai. CN
Zhao, Xiaoling; Xingtai Peoples Hospital. Department of Cancer Laboratory. Xingtai. CN
He, Yuanyuan; Xingtai Peoples Hospital. Department of Pediatrics. Xingtai. CN
Wei, Lei; Shanxi Provincial Peoples Hospital. Department of Cardiovascular Surgery. Taiyuan. CN
Kong, Nana; Xingtai Peoples Hospital. Department of Obstetrics. Xingtai. CN

Braz. j. med. biol. res ; 57: e13253, fev.2024. tab, graf

Article em En | LILACS-Express | LILACS | ID: biblio-1574233

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

Jun N-terminal kinase pathway-associated phosphatase (JKAP) regulates CD4+ T-cell differentiation and immunity, which are linked to mental disorders. This study aimed to explore the relationships between JKAP and T helper 17 (Th17)/regulatory T (Treg) ratio, as well as their associations with anxiety and depression in postpartum women. Serum JKAP were measured by enzyme-linked immunosorbent assay and blood Th17 and Treg cells were measured by flow cytometry in 250 postpartum women. Anxiety and depression were evaluated by the 6-item State-Trait Anxiety Inventory (STAI6) and Edinburgh Postnatal Depression Scale (EPDS). Anxiety and depression rates were 22.0 and 28.4%, respectively, among postpartum women. Notably, JKAP was negatively associated with the STAI6 (P=0.002) and EPDS scores (P<0.001) in postpartum women and was lower in postpartum women with anxiety (P=0.023) or depression (P=0.002) than in those without. Moreover, JKAP was inversely related to Th17 cells and Th17/Treg ratio but positively correlated with Treg cells in postpartum women (all P<0.001). Interestingly, Th17 cells and Th17/Treg ratio were both positively associated with STAI6 and EPDS scores in postpartum women (all P<0.001). Furthermore, Th17 cells and Th17/Treg ratio were lower in postpartum women with anxiety or depression than in those without (all P<0.01). Nevertheless, Treg cells were not linked to anxiety or depression in postpartum women. JKAP was negatively associated with Th17 cells and Th17/Treg ratio; moreover, they all related to anxiety and depression in postpartum women, indicating that JKAP may be involved in postpartum anxiety and depression via interactions with Th17 cells.

Palavras-chave

Anxiety; Depression; Jun N-terminal kinase pathway-associated phosphatase; Postpartum women; T helper 17 cells

Texto completo

Adicionar na Minha BVS

Imprimir

XML

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Braz. j. med. biol. res Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo

Adicionar na Minha BVS

Imprimir

XML

Buscar no Google