Your browser doesn't support javascript.
loading
Improvement effect of compound Ento-PB on oxazolone-induced ulcerative colitis in rats
Fan, Zhi; Chen, Jinhu; Wei, Jia; Yang, ZhiBin; Xiao, Huai; Liu, Heng.
Afiliação
  • Fan, Zhi; Dali University. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical. Dali. CN
  • Chen, Jinhu; Dali University. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical. Dali. CN
  • Wei, Jia; Dali University. National-Local Joint Engineering Research Center of Entomoceutics. Dali. CN
  • Yang, ZhiBin; Dali University. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical. Dali. CN
  • Xiao, Huai; Dali University. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical. Dali. CN
  • Liu, Heng; Dali University. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical. Dali. CN
Acta cir. bras ; Acta cir. bras;39: e395524, 2024. graf
Article em En | LILACS-Express | LILACS, VETINDEX | ID: biblio-1573645
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Purpose:

To investigate the impact of the Chinese medicine compound Ento-PB on oxazolone (OXZ)-induced ulcerative colitis (UC) in rats.

Methods:

UC rats induced by OXZ were treated with Ento-PB. The damage to the colon was assessed using several measures, including the disease activity index (DAI), colon length, colon weight/length ratio, colonic mucosal damage index, and histological score. The levels of interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13 (IL-13), epidermal growth factor (EGF), inducible nitric oxide synthase, and total nitric oxide synthase (tNOS) in rat serum, as well as the levels of tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) in rat colon tissue, were determined using enzyme-linked immunosorbent assay and conventional kits.

Results:

After being treated with Ento-PB, the DAI score and macroscopic lesion score of OXZ-induced UC rats were significantly reduced. Ento-PB prevented the shortening of rat colons, reduced the ratio of colon weight to length, and improved colon tissue lesions. Meanwhile, Ento-PB could significantly inhibit the activities of proinflammatory cytokines TNF-α, IL-13, and MPO, as well as tNOS and iNOS, while upregulating the expression of anti-inflammatory cytokines IL-4 and IL-10. Moreover, a significant increase in the expression level of EGF was observed in UC rats treated with Ento-PB, indicating that Ento-PB could enhance the repair of damaged intestinal epithelial tissue.

Conclusions:

Ento-PB demonstrates significant anti-UC activities in OXZ-induced UC rats by regulating the expression levels of inflammatory factors and promoting the repair of colon tissue. This study provides scientific evidence to support the further development of Ento-PB.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil