Language impairments in Alzheimer's disease: What changes can be found between mild and moderate stages of the disease?
Clinics
; Clinics;79: 100412, 2024. tab
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1569144
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Objective:
To investigate how language deteriorates over the Alzheimer's Disease course.Methods:
A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.Results:
A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.Conclusion:
The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
/
Reino Unido
País de publicação:
Brasil