Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives

Zang, Dongdong; Yang, Xuemei; Wang, Hao; Li, Zhenxing; Ma, Yanjun; Liu, Jianxi; Mei, Xi; Li, Shupeng; Feng, Jinxing; Shi, Xin; Tan, Zhen

Zang, Dongdong; Yang, Xuemei; Wang, Hao; Li, Zhenxing; Ma, Yanjun; Liu, Jianxi; Mei, Xi; Li, Shupeng; Feng, Jinxing; Shi, Xin; Tan, Zhen.

Afiliação

Zang, Dongdong; Shenzhen Childrens Hospital. Department of Neonatology. Shenzhen City. CN
Yang, Xuemei; Shenzhen University. Shenzhen University Clinical Medical Academy. Shenzhen University General Hospital. Shenzhen City. CN
Wang, Hao; Shenzhen Peoples Hospital. Department of Neurosurgery. Shenzhen City. CN
Li, Zhenxing; Shenzhen University. Shenzhen University Clinical Medical Academy. Shenzhen University General Hospital. Shenzhen City. CN
Ma, Yanjun; Shenzhen Ruijian Biotechnology Co., LTD. Shenzhen City. CN
Liu, Jianxi; Shenzhen Ruijian Biotechnology Co., LTD. Shenzhen City. CN
Mei, Xi; Zhuhai Pengkun Biomedicine Technology Co. LTD. Zhuhai City. CN
Li, Shupeng; Peking University. School of Chemical Biology and Biotechnology. State Key Laboratory of Oncogenomics. Shenzhen City. CN
Feng, Jinxing; Shenzhen Childrens Hospital. Department of Neonatology. Shenzhen City. CN
Shi, Xin; Shenzhen University. Shenzhen University Clinical Medical Academy Centre. Shenzhen University General Hospital. Shenzhen City. CN
Tan, Zhen; Shenzhen Childrens Hospital. Department of Neonatology. Shenzhen City. CN

Clinics ; Clinics;79: 100435, 2024. graf

Article em En | LILACS-Express | LILACS | ID: biblio-1569136

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

Abstract

Objective:

This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects.

Methods:

Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds.

Results:

In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group.

Conclusion:

The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short.

Palavras-chave

Antidepressant; Behavioral Sensitization Test; Conditioned Place Preference Test; Forced Swimming Test; Hydroxynorketamine and its Derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil

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