Benzbromarone as adjuvant therapy for cystic fibrosis lung disease: a pilot clinical trial
J. bras. pneumol
; J. bras. pneumol;50(3): e20230292, 2024. tab, graf
Article
em En
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LILACS-Express
| LILACS
| ID: biblio-1564729
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Objective:
Cystic fibrosis (CF) affects multiple organs, the most severe consequences being observed in the lungs. Despite significant progress in developing CF transmembrane conductance regulator-specific treatments for CF lung disease, exploring alternative CF-targeted medications seems reasonable. We sought to evaluate the potential beneficial effects of oral benzbromarone as an adjuvant therapy in CF patients with reduced lung function.Methods:
This was a prospective open-label pilot study of oral benzbromarone (100 mg/day) administered once daily for 90 days. Patients were followed at a tertiary referral center in southern Brazil. Safety was assessed by the number of reported adverse events. Secondary objectives included percent predicted FEV1 (FEV1%) and pulmonary exacerbations.Results:
Ten patients were enrolled. Benzbromarone was found to be safe, with no serious drug-related adverse events. Eight patients completed the study; the median relative change in FEV1% tended to increase during the treatment, showing an 8% increase from baseline at the final visit. However, a nonparametric test showed that the change was not significant (p = 0.06). Of a total of ten patients, only one experienced at least one pulmonary exacerbation during the study.Conclusions:
Oral benzbromarone appears to be safe, and improved FEV1% has been observed in patients with CF. Further assessment in larger trials is warranted to elucidate whether oral benzbromarone can be a potential adjuvant therapy for CF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Idioma:
En
Revista:
J. bras. pneumol
Assunto da revista:
PNEUMOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
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Project document
País de afiliação:
Brasil
/
Alemanha
País de publicação:
Brasil