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Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population
Li, Yingyi; Cai, Hehui; Lin, Yancheng; Huang, Zhipeng; Zhou, Apei; Huang, Tianhao; Zeng, Yue-e; Ye, Meizhen; Guo, Guiyuan; Huang, Zicheng.
Afiliação
  • Li, Yingyi; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Cai, Hehui; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Clinical Laboratory. Quanzhou. CN
  • Lin, Yancheng; HI. Q Biomedical Laboratory. Quanzhou. CN
  • Huang, Zhipeng; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Zhou, Apei; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Huang, Tianhao; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Zeng, Yue-e; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Ye, Meizhen; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Guo, Guiyuan; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
  • Huang, Zicheng; The First Hospital of Quanzhou Affiliated to Fujian Medical University. Department of Gastroenterology. Quanzhou. CN
Arch. endocrinol. metab. (Online) ; 68: e230195, 2024. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1556927
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Objective:

The study aims to explore the relationship between lipoprotein lipase (LPL) variants and hyperlipidemic acute pancreatitis (HLAP) in the southeastern Chinese population. Subjects and

methods:

In total, 80 participants were involved in this study (54 patients with HLAP and 26 controls). All coding regions and intron-exon boundaries of the LPL gene were sequenced. The correlations between variants and phenotypes were also analysed.

Results:

The rate of rare LPL variants in the HLAP group is 14.81% (8 of 54), higher than in controls. Among the detected four variants (rs3735959, rs371282890, rs761886494 and rs761265900), the most common variant was rs371282890. Further analysis demonstrated that subjects with rs371282890 "GC" genotype had a 2.843-fold higher risk for HLAP (odds ratio [OR] 2.843, 95% confidence interval [CI] 1.119-7.225, p = 0.028) than subjects with the "CC" genotype. After adjusting for sex, the association remained significant (adjusted OR 3.083, 95% CI 1.208-7.869, p = 0.018). Subjects with rs371282890 "GC" genotype also exhibited significantly elevated total cholesterol, triglyceride and non-high-density lipoprotein cholesterol levels in all the participants and the HLAP group (p < 0.05).

Conclusion:

Detecting rare variants in LPL might be valuable for identifying higher-risk patients with HLAP and guiding future individualised therapeutic strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil