Your browser doesn't support javascript.
loading
Effects of anabolic androgenic steroids in athletes on left ventricle systolic and diastolic function: a systematic review and meta-analysis
Guida, Camila Mota; Castro, Ana Beatriz Junqueira de; Ferreira, André Luiz Carvalho; Lima, Ana Emanuela; Gonzalez, Maria E. Benitez; Neves, Henrique Alexsander; Santos, Camila Dalcomuni dos; Madruga, Gabriela; Vilalva, Kelvin Henrique; Sierraalta, Wendy.
Afiliação
  • Guida, Camila Mota; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Castro, Ana Beatriz Junqueira de; s.af
  • Ferreira, André Luiz Carvalho; s.af
  • Lima, Ana Emanuela; s.af
  • Gonzalez, Maria E. Benitez; s.af
  • Neves, Henrique Alexsander; s.af
  • Santos, Camila Dalcomuni dos; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Madruga, Gabriela; s.af
  • Vilalva, Kelvin Henrique; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Sierraalta, Wendy; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
J. Am. Coll. Cardiol ; J. Am. Coll. Cardiol;83(13 Suppl. A)Apr. 2024. tab.
Article em En | CONASS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1551748
Biblioteca responsável: BR79.1
ABSTRACT

BACKGROUND:

The use of anabolic androgenic steroids (AAS) among athletes has been linked to pathological structural and functional cardiac changes. However, the studies are small, and the results are inconsistent.

METHODS:

We conducted a systematic review and meta-analysis of echocardiographic outcomes comparing athletes with prolonged use of AAS (at least 2 years of use) versus sex and age- matched athletes who were did not use AAS. PubMed, Cochrane, and embase were searched. A random-effects model was used to calculate mean differences (MDs), with 95% confidence intervals (CI). Statistical analyses were performed using Review Manager 5.4.1.

RESULTS:

We included 17 studies comprising 1,023 athletes, of whom 543 (53%) were AAS users. The mean age ranged to 24.2 to 43 years. Compared with non-AAS users, athletes who used AAS exhibited a significant increase in interventricular septal wall thickness (MD 1.33 mm; 95% CI [0.8,1.89], p<0.001), a reduction in left ventricular ejection fraction (MD 2.77 %; 95% CI [-4.2,-1.34], p<0.001;Figure 1B) , and worsening of global longitudinal strain (MD 3.39%; 95% CI [2.88,3.91], p<0.001;Figure 1B). Additionally, there was a significant reduction in the E/A ratio (MD -0.21; 95% CI [-0.35,-0.07], p=0.003) and an increase in the E/e' ratio (MD 1.71; 95% CI [0.96,2.46], p<0.001).

CONCLUSION:

Our findings suggest that prolonged use of AAS in athletes is associated with increased left ventricular wall thickness and worsening of systolic and diastolic parameters.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 06-national / BR Base de dados: CONASS / SES-SP / SESSP-IDPCPROD Assunto principal: Disfunção Ventricular Esquerda / Atletas / Esteróides Androgênicos Anabolizantes Idioma: En Revista: J. Am. Coll. Cardiol Ano de publicação: 2024 Tipo de documento: Article / Congress and conference
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 06-national / BR Base de dados: CONASS / SES-SP / SESSP-IDPCPROD Assunto principal: Disfunção Ventricular Esquerda / Atletas / Esteróides Androgênicos Anabolizantes Idioma: En Revista: J. Am. Coll. Cardiol Ano de publicação: 2024 Tipo de documento: Article / Congress and conference