Effects of anabolic androgenic steroids in athletes on left ventricle systolic and diastolic function: a systematic review and meta-analysis
J. Am. Coll. Cardiol
; J. Am. Coll. Cardiol;83(13 Suppl. A)Apr. 2024. tab.
Article
em En
| CONASS, SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1551748
Biblioteca responsável:
BR79.1
ABSTRACT
BACKGROUND:
The use of anabolic androgenic steroids (AAS) among athletes has been linked to pathological structural and functional cardiac changes. However, the studies are small, and the results are inconsistent.METHODS:
We conducted a systematic review and meta-analysis of echocardiographic outcomes comparing athletes with prolonged use of AAS (at least 2 years of use) versus sex and age- matched athletes who were did not use AAS. PubMed, Cochrane, and embase were searched. A random-effects model was used to calculate mean differences (MDs), with 95% confidence intervals (CI). Statistical analyses were performed using Review Manager 5.4.1.RESULTS:
We included 17 studies comprising 1,023 athletes, of whom 543 (53%) were AAS users. The mean age ranged to 24.2 to 43 years. Compared with non-AAS users, athletes who used AAS exhibited a significant increase in interventricular septal wall thickness (MD 1.33 mm; 95% CI [0.8,1.89], p<0.001), a reduction in left ventricular ejection fraction (MD 2.77 %; 95% CI [-4.2,-1.34], p<0.001;Figure 1B) , and worsening of global longitudinal strain (MD 3.39%; 95% CI [2.88,3.91], p<0.001;Figure 1B). Additionally, there was a significant reduction in the E/A ratio (MD -0.21; 95% CI [-0.35,-0.07], p=0.003) and an increase in the E/e' ratio (MD 1.71; 95% CI [0.96,2.46], p<0.001).CONCLUSION:
Our findings suggest that prolonged use of AAS in athletes is associated with increased left ventricular wall thickness and worsening of systolic and diastolic parameters.
Texto completo:
1
Coleções:
06-national
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BR
Base de dados:
CONASS
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SES-SP
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SESSP-IDPCPROD
Assunto principal:
Disfunção Ventricular Esquerda
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Atletas
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Esteróides Androgênicos Anabolizantes
Idioma:
En
Revista:
J. Am. Coll. Cardiol
Ano de publicação:
2024
Tipo de documento:
Article
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Congress and conference