Prevalence of IgA anti-tissue transglutaminase antibody in a cohort of iranians patients with inflammatory bowel disease

Memar, Bahram; Naghavi, Maryam; Vosoughinia, Hassan; Amouian, Sakineh; Farzanehfar, MohammadReza; Namdar, Ali Beheshti; Ahadi, Mitra; Mehrad-Majd, Hassan

Memar, Bahram; Naghavi, Maryam; Vosoughinia, Hassan; Amouian, Sakineh; Farzanehfar, MohammadReza; Namdar, Ali Beheshti; Ahadi, Mitra; Mehrad-Majd, Hassan.

Afiliação

Memar, Bahram; Mashhad University of Medical Sciences. Surgical Oncology Research Center. Mashhad. IR
Naghavi, Maryam; Mashhad University of Medical Sciences. Faculty of Medicine. Department of Gastroenterology and Hepatology. Mashhad. IR
Vosoughinia, Hassan; Mashhad University of Medical Sciences. Faculty of Medicine. Department of Gastroenterology and Hepatology. Mashhad. IR
Amouian, Sakineh; Mashhad University of Medical Sciences. Surgical Oncology Research Center. Mashhad. IR
Farzanehfar, MohammadReza; Mashhad University of Medical Sciences. Faculty of Medicine. Department of Gastroenterology and Hepatology. Mashhad. IR
Namdar, Ali Beheshti; Mashhad University of Medical Sciences. Cancer Molecular Pathology Research Center. Mashhad. IR
Ahadi, Mitra; Mashhad University of Medical Sciences. Faculty of Medicine. Department of Gastroenterology and Hepatology. Mashhad. IR
Mehrad-Majd, Hassan; Mashhad University of Medical Sciences. Cancer Molecular Pathology Research Center. Mashhad. IR

J. coloproctol. (Rio J., Impr.) ; 43(4): 280-285, Oct.-Dec. 2023. tab

Article em En | LILACS | ID: biblio-1528947

Biblioteca responsável: BR545.3

ABSTRACT

ABSTRACT

Background and

Aims:

Some studies have reported the coexistence of inflammatory bowel disease (IBD) and celiac disease (CD). However, the prevalence of anti-tissue transglutaminase antibodies (IgA and IgG) and their screening value in patients with IBD is not yet clear. This study aimed to assess the prevalence of IgA anti-tTG and its potential correlation with disease status in patients with IBD. Materials and

Methods:

This cross-sectional study was conducted on 110 patients with confirmed IBD diagnosis at Ghaem Hospital, Mashhad, Iran. For each patient, all demographic and clinical data including age, extra intestinal manifestations, underlying diseases, types of diseases, and surgical history were collected. IgA anti-tissue transglutaminase titers were assessed by enzyme-linked immunosorbent assay.

Results:

None of the patients with IBD were positive for IgA anti-tTG antibodies, with a mean titer of 3.31 ± 1.3 AU/mL. Also, the mean titers were not associated with age, gender and various disease clinical features including the disease history, underlying disease, diagnosis type, extraintestinal manifestations, and surgery history.

Conclusion:

No significant prevalence pattern of IgA anti-tTG antibody was observed in patients with IBD. Accordingly, serological screening for CeD is not recommended in IBD patients, unless in a relevant clinical CeD suspicion. (AU)

Assuntos

Humanos; Masculino; Feminino; Adolescente; Adulto; Pessoa de Meia-Idade; Imunoglobulina A; Doenças Inflamatórias Intestinais; Doença Celíaca; Estudos de Coortes; Anticorpos

Palavras-chave

Celiac disease; Crohn's disease; IgA anti-tissue transglutaminase; Inflammatory bowel disease; Ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Imunoglobulina A / Doenças Inflamatórias Intestinais / Doença Celíaca Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J. coloproctol. (Rio J., Impr.) Assunto da revista: Cirurgia / Doenas Retais / Doenas do Colo / GASTROENTEROLOGIA / Cirurgia Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil

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