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Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola
Quintas, Angelina Edna; Dias, Cláudia Camila; Cogle, Adis Del Carmen; Cordeiro, Lemuel; Sarmento, António.
Afiliação
  • Quintas, Angelina Edna; Faculdade de Medicina da Universidade do Porto. Departamento de Medicina Comunitária. Informação e Decisão em Saúde e Centro de Pesquisa em Tecnologias e Serviços de Saúde. Porto. PT
  • Dias, Cláudia Camila; Universidade do Porto. Faculdade de Medicina. Departamento de Medicina Comunitária, Informação e Ciências da Decisão em Saúde (MEDCIDS) e Unidade de Gestão do Conhecimento. Porto. PT
  • Cogle, Adis Del Carmen; Clínica Girassol in Luanda. Department of Hematology. Luanda. AO
  • Cordeiro, Lemuel; Clínica Girassol. Department of Education Office. Luanda. AO
  • Sarmento, António; Centro Hospitalar Universitário São João. Serviço de Doenças Infecciosas. Porto. PT
Braz. j. infect. dis ; Braz. j. infect. dis;27(6): 103704, 2023. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1528090
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Background The transmission of diseases by blood products continues to be a worldwide health problem, especially in Africa. Seroprevalence rates of the Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), Syphilis, and Coinfection in Angola are poorly documented. This study aims to identify the seroprevalence of markers with positive results for Hepatitis B, C, HIV, Syphilis, and Coinfection in blood donors. Material and methods A retrospective study was conducted using a database of positive serological markers for these infections and coinfection in 2734 blood donors traced from 2011 to 2016 in Luanda, Angola. The Chi-Square test (χ2) or Fisher's exact test was used to evaluate serological positivity and donors' characteristics. A p-value < 0.05 was considered statistically significant. Results 2734 blood donors aged 18 to 64 (median age 32 ± 9) were screened from 2011 to 2016. 73.9 % of the donors were positive for one Transfusion-Transmitted Infection (TTI), and 5.9 % showed evidence of multiple infections. The overall seroprevalence rate was 50.2 % (1373) for HBV, 20 % (436) for Syphilis, 7 % (191) for HIV, 5.1 % (140) for HCV, and 5.8 % for coinfected donors. 2467 (90 %) were men, and 267 (10 %) were women. We identified 118 (5.8 %) coinfected donors. Of those, 40 (33.9 %) simultaneously presented Hepatitis B virus surface antigen (HBsAg)/Syphilis, 24 (20.3 %) HBsAg/HIV, 22 (18.6 %) HBsAg/HCV, 20 (16.9 %) HIV/Syphilis, 8 (6.8 %) HCV/Syphilis, and 4 (3.4 %) HIV/HCV. Conclusion A high transfusion-transmissible infection prevalence was found compared to some countries in Sub-Saharan Africa. Therefore, intensifying the screening for these transfusion-transmitted infections in blood donors is critical to ensure blood safety.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Angola / Portugal País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Angola / Portugal País de publicação: Brasil