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Relationship of irisin expression with metabolic alterations and cardiovascular risk in type 2 diabetes mellitus: a preliminary study
Mathia, Vanessa Lopes; Mendonça, Maria Isabel Sacchi; Simões, Diogo Pimenta; Perez, Matheus Moreira; Alves, Beatriz da Costa Aguiar; Encinas, Jéssica Freitas Araújo; Raimundo, Joyce Regina Santos; Arcia, Catherine Giovanna Costas; Murad, Neif; Fonseca, Fernando Luiz Affonso; Veiga, Glaucia Luciano da.
Afiliação
  • Mathia, Vanessa Lopes; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Mendonça, Maria Isabel Sacchi; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Simões, Diogo Pimenta; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Perez, Matheus Moreira; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Alves, Beatriz da Costa Aguiar; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Encinas, Jéssica Freitas Araújo; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Raimundo, Joyce Regina Santos; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Arcia, Catherine Giovanna Costas; Centro Universitário São Camilo. São Paulo. BR
  • Murad, Neif; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Fonseca, Fernando Luiz Affonso; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
  • Veiga, Glaucia Luciano da; Centro Universitário FMABC. Clinical Analysis Laboratory. Santo André. BR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);69(12): e20230812, 2023. tab
Article em En | LILACS-Express | LILACS | ID: biblio-1521504
Biblioteca responsável: BR1.1
ABSTRACT
SUMMARY

OBJECTIVE:

The aim of this study was to investigate the role of irisin in type 2 diabetes mellitus and its association with metabolic alterations and obesity.

METHODS:

A cross-sectional case-control study was conducted on participants treated at Centro Universitário FMABC between August 2018 and July 2019, by comparing a control group (n=14) with type 2 diabetes mellitus patients (n=16). The control group consisted of participants aged above 21 years with no chronic diseases, diabetes, smoking, or illicit drug use. The type 2 diabetes mellitus group included patients aged above 21 years, who were diagnosed with type 2 diabetes for at least 5 years (glycated hemoglobin>7%). Exclusion criteria were not willing to continue, recent hospitalization, and failure to meet inclusion criteria. Biochemical parameters included blood glucose, glycated hemoglobin, plasma irisin levels, and irisin gene expression in peripheral blood.

RESULTS:

Type 2 diabetes mellitus patients exhibited significantly higher plasma glucose levels [143 (40) vs. 92 (13) mg/dL, *p<0.05] and glycated hemoglobin levels [7.1% (1.6) vs. 5.6% (0.5), *p<0.05] compared to the control group. Irisin gene expression in type 2 diabetes mellitus patients was lower 0.02288 (0.08050) than the control group 8.506e-006 (1.412e-005) (p=0.06). Correlation analysis revealed a positive association between irisin expression and body mass index in type 2 diabetes mellitus (Rho=0.5221, 95%CI -0.058 to 0.838, p=0.06), while plasma irisin showed a negative correlation with body mass index (Rho=-0.656, 95%CI -0.836 to 0.215, p=0.03). No significant correlations were found between plasma glucose or glycated hemoglobin levels and irisin expression.

CONCLUSION:

The data suggests that body mass index directly influences plasma irisin levels and the regulation of irisin gene expression, possibly linking irisin to adiposity changes observed in obesity-related type 2 diabetes mellitus.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2023 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Rev. Assoc. Med. Bras. (1992, Impr.) Assunto da revista: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Ano de publicação: 2023 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil