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Association of Intermittent and Continuous Hypoxaemia with Carotid and Brachial Arterial Intima-Media Thicknesses
Asker, S; Asker, M; Ozgokce, M; Ozbay, B.
Afiliação
  • Asker, S; Van Yuksek Ihtisas Training and Research Hospital. Department of Chest Diseases. Van. TR
  • Asker, M; Van Yuksek Ihtisas Training and Research Hospital. Department of Cardiology. Van. TR
  • Ozgokce, M; Van Regional Training and Research Hospital. Department of Radiology. Van. TR
  • Ozbay, B; Mugla University Faculty of Medicine. Department of Chest Diseases. Mugla. TR
West Indian med. j ; West Indian med. j;69(7): 478-482, 2021. tab
Article em En | LILACS-Express | LILACS | ID: biblio-1515711
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Objective:

To assess the carotid and brachial arteries' intima-media thicknesses (IMTs) in cases with intermittent (obstructive sleep apnoea syndrome (OSAS)) and continuous (chronic obstructive pulmonary disease (COPD)) hypoxaemia together with other confounding demographic and biochemical factors.

Methods:

The study was prospectively performed on 197 patients allocated in three groups 80 with severe OSAS, 80 with severe COPD patients and 37 healthy controls. These groups were compared in terms of demographics, biochemical markers and IMTs of the right and left carotid and brachial arteries.

Results:

Carotid and brachial arterial IMTs were found to be higher in both patient groups than the control group (p < 0.001). Similarly, levels of haemoglobin, haematocrit, cholesterol, triglycerides, low-density lipoproteins (LDL), C-reactive protein and D (domain)-dimer were significantly increased in patient groups. Oxygen saturations (p < 0.001) and ejection fractions (p = 0.001) were found to be worse and D-dimer levels (p = 0.010) were elevated more prominently in COPD patients, whereas, cholesterol (p < 0.001), hemoglobin (p = 0.004) and LDL (p = 0.001) levels were higher in the OSAS group. Except the right carotid IMT, which was increased significantly in OSAS patients, IMT measurements were similar in the OSAS and COPD groups (p < 0.001).

Conclusion:

We have shown that both intermittent and continuous hypoxia result in remarkable alterations in carotid IMT and brachial IMT. Further prospective trials are warranted to confirm and extend these findings, including the biochemical markers, which may aid in the diagnosis and follow-up of patients suffering from hypoxaemia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: West Indian med. j Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia País de publicação: Jamaica
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: West Indian med. j Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia País de publicação: Jamaica