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Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
Bordon, Karla C. F; Wiezel, Gisele A; Amorim, Fernanda G; Arantes, Eliane C.
Afiliação
  • Bordon, Karla C. F; University of São Paulo. Ribeirão Preto. BR
  • Wiezel, Gisele A; University of São Paulo. Ribeirão Preto. BR
  • Amorim, Fernanda G; University of São Paulo. Ribeirão Preto. BR
  • Arantes, Eliane C; University of São Paulo. Ribeirão Preto. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;21: 1-12, 31/03/2015. ilus, tab
Article em En | LILACS, VETINDEX | ID: biblio-1484615
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
Hyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammation and allergy, among others. Hyaluronidases are widely distributed in nature and the enzymes from mammalian spermatozoa, lysosomes and animal venoms belong to the subclass EC 3.2.1.35. To date, only five three-dimensional structures for arthropod venom hyaluronidases (Apis mellifera and Vespula vulgaris) were determined. Additionally, there are four molecular models for hyaluronidases fromMesobuthus martensii, Polybia paulista and Tityus serrulatus venoms. These enzymes are employed as adjuvants to increase the absorption and dispersion of other drugs and have been used in various off-label clinical conditions to reduce tissue edema. Moreover, a PEGylated form of a recombinant human hyaluronidase is currently under clinical trials for the treatment of metastatic pancreatic cancer. This review focuses on the arthropod venom hyaluronidases and provides an overview of their biochemical properties, role in the envenoming, structure/activity relationship, and potential medical and biotechnological applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Venenos de Artrópodes / Hialuronoglucosaminidase / Animais Peçonhentos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Venenos de Artrópodes / Hialuronoglucosaminidase / Animais Peçonhentos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil