Hepatotoxicity and oxidative stress induced by Naja haje crude venom
J. venom. anim. toxins incl. trop. dis
; J. venom. anim. toxins incl. trop. dis;20: 1-10, 04/02/2014. tab, ilus
Article
em En
| LILACS, VETINDEX
| ID: biblio-1484587
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Snake venoms are synthesized and stored in venom glands. Most venoms are complex mixtures of several proteins, peptides, enzymes, toxins and non-protein components. In the present study, we investigated the oxidative stress and apoptosis in rat liver cells provoked by Naja haje crude injection (LD50) after four hours. Wistar rats were randomly divided into two groups, the control group was intraperitoneally injected with saline solution while LD50-dose envenomed group was intraperitoneally injected with venom at a dose of 0.025 μg/kg of body weight. Animals were killed four hours after the injection. Lipid peroxidation, nitric oxide and glutathione levels were measured as oxidative markers in serum and liver homogenate. In addition, liver function parameters and activities of antioxidant enzymes were determined.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
VETINDEX
Assunto principal:
Ratos
/
Venenos de Serpentes
/
Apoptose
/
Estresse Oxidativo
Limite:
Animals
Idioma:
En
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Arábia Saudita
/
Espanha
País de publicação:
Brasil