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Neurobehavioral and neuroprotector effects of caffeine in animal models
Villanueva-García, Dina; Mota-Rojas, Daniel; Miranda-Cortés, Agatha; Mora-Medina, Patricia; Hernández-Avalos, Ismael; Casas-Alvarado, Alejandro; Olmos-Hernández, Adriana; Martínez-Burnes, Julio.
Afiliação
  • Villanueva-García, Dina; National Institute of Health HospitalInfantil de México Federico Gómez. Division of Neonatology. Mexico City. MX
  • Mota-Rojas, Daniel; Universidad Autónoma Metropolitana (UAM). Department of Animal Production and Agriculture (DPAA). Neurophysiology, Behavior, and Animal Welfare Assessment. Mexico City. MX
  • Miranda-Cortés, Agatha; Universidad Nacional Autónoma de México (UNAM). FESC. Department of Biological Science. Clinical Pharmacology and Veterinary Anaesthesia. MX
  • Mora-Medina, Patricia; Universidad Nacional Autónoma de México (UNAM). Facultad de Estudios Superiores Cuautitlán. Livestock Science Department. State of Mexico. MX
  • Hernández-Avalos, Ismael; Universidad Nacional Autónoma de México (UNAM). FESC. Department of Biological Science. Clinical Pharmacology and Veterinary Anaesthesia. MX
  • Casas-Alvarado, Alejandro; Universidad Autónoma Metropolitana (UAM). Department of Animal Production and Agriculture (DPAA). Neurophysiology, Behavior, and Animal Welfare Assessment. Mexico City. MX
  • Olmos-Hernández, Adriana; Secretaría de Salud (SSA). National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra" (INRLGII). Bioterio y Cirugía Experimental. Mexico City. MX
  • Martínez-Burnes, Julio; Universidad Autónoma de Tamaulipas. Facultad de Medicina Veterinaria y Zootecnia. Graduate and Research Department. Victoria City. MX
J. Anim. Behav. Biometeorol ; 8(4): 298-307, Oct. 2020. ilus
Article em En | VETINDEX | ID: biblio-1484322
Biblioteca responsável: BR68.1
Localização: BR68.1
ABSTRACT
This review aims to analyze and contrast the neurological effects associated with the use of caffeine on neurobehavior and neuroprotection in animal models. Caffeine belongs to the group of methylxanthines that exert a direct effect on adenosine receptors associated with inhibitory or excitatory G proteins, generating modification of cyclic AMP activity and intracellular calcium flow which produces alterations in the modulation system of the neurotransmitters dopamine and glutamate. The regulation of the neurotransmission systems generates protection against the inflammation of the central nervous system, by activation of the microglia and reinforcement of the blood-brain barrier. This drug will also restore cognition or prevent memory loss in Parkinson's or Alzheimer's diseases. It is important to establish new study models in other species to assess whether the behavior of the molecule is similar and to obtain other clinical applications in its behavioral and neuroprotective effects.
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Estimulantes do Sistema Nervoso Central / Hipotálamo Limite: Animals Idioma: En Revista: J. Anim. Behav. Biometeorol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Base de dados: VETINDEX Assunto principal: Estimulantes do Sistema Nervoso Central / Hipotálamo Limite: Animals Idioma: En Revista: J. Anim. Behav. Biometeorol Ano de publicação: 2020 Tipo de documento: Article