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Study of antidiabetic activity of two novel Schiff base derived dibromo and dichloro substituted compounds in streptozotocin-nicotinamide-induced diabetic rats: pilot study
Saremi, Kamelia; Rad, Sima Kianpour; Shahnavaz, Zohreh; Majid, Nazia Binti Abdul.
Afiliação
  • Saremi, Kamelia; University of Malaya. Faculty of Science. Institute of Biological Science. Kuala Lumpur. MY
  • Rad, Sima Kianpour; The University of Adelaide. Adelaide Medical School. Discipline of Surgery. Adelaide. AU
  • Shahnavaz, Zohreh; Jiangsu University. School of Materials Science and Engineering. Jiangsu. CN
  • Majid, Nazia Binti Abdul; University of Malaya. Faculty of Science. Institute of Biological Science. Kuala Lumpur. MY
Braz. J. Pharm. Sci. (Online) ; 59: e21159, 2023. tab, graf
Article em En | LILACS | ID: biblio-1447571
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
Abstract Schiff bases are aldehyde-or ketone-like chemical compounds in which an imine or azomethine group replaces the carbonyl group. Such compounds show various beneficial biological activities, such as anti-inflammation and antioxidants. The present study addresses comprehensiveevaluation of antidiabetic effect of two novel dibromides and dichlorides substituted Schiff bases substituted Schiff bases (2,2'-[1,2-cyclohexanediylbis (nitriloethylidyne)]bis[4-chlorophenol] (CNCP) and 2, 2'-[1,2-cyclohexanediylbis(nitriloethylidyne)]bis[4-bromophenol] (CNBP) with two different doses, high (LD) and low (LD) in streptozotocin and nicotinamide induced diabetic rats. The rats were separated into normal, untreated, treated and reference groups. Except for the normal group, diabetes traits were induced in the rest animals. Insulin level was measured, and the effect of the compounds on biochemical parameters of liver function and lipid profile were evaluated. High glucose and decreased insulin level are observed in the groups. The histological evaluation confirms that the hepatic architecture in the treated animals with a low dose of CNCP is quite similar to that of the normal hepatic structure and characterized by normal central vein, hepatocytes without any fatty alterations and mild red blood cell infiltration. CNCP (LD) and CNBP (HD) are more successful in enhancing cell survival in the diabetic rat's liver and can be responsible for causing much healthier structure and notable morphology improvement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Bases de Schiff / Estreptozocina / Hipoglicemiantes / Nicotinamidase Limite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália / China / Malásia País de publicação: Brasil
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Bases de Schiff / Estreptozocina / Hipoglicemiantes / Nicotinamidase Limite: Animals Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália / China / Malásia País de publicação: Brasil